PT  - JOURNAL ARTICLE
AU  - Kopp, Michael
AU  - Hermisson, Joachim
TI  - Adaptation of a Quantitative Trait to a Moving Optimum
AID  - 10.1534/genetics.106.067215
DP  - 2007 May 01
TA  - Genetics
PG  - 715--719
VI  - 176
IP  - 1
4099  - http://www.genetics.org/content/176/1/715.short
4100  - http://www.genetics.org/content/176/1/715.full
SO  - Genetics2007 May 01; 176
AB  - We investigate adaptive evolution of a quantitative trait under stabilizing selection with a moving optimum. We characterize three regimes, depending on whether (1) the beneficial mutation rate, (2) the fixation time, or (3) the rate of environmental change is the limiting factor for adaptation. If the environment is rate limiting, mutations with a small phenotypic effect are prefered over large mutations, in contrast to standard theory.