RT Journal Article
SR Electronic
T1 A Clarification of the Hardy–Weinberg Law
JF Genetics
JO Genetics
FD Genetics Society of America
SP 1695
OP 1697
DO 10.1534/genetics.106.057042
VO 174
IS 3
A1 Stark, Alan E.
YR 2006
UL http://www.genetics.org/content/174/3/1695.abstract
AB C. C. Li showed that Hardy–Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting from any genotypic distribution at a single locus with two alleles, the same in each sex, HWP can be reached in one round of nonrandom mating with no change in allele frequency. In the model that demonstrates this fact, random mating is represented by a single point in a continuum of nonrandom possibilities.