RT Journal Article
SR Electronic
T1 The Mod(mdg4) Component of the Su(Hw) Insulator Inserted in the <em>P</em> Transposon Can Repress Its Mobility in <em>Drosophila melanogaster</em>
JF Genetics
JO Genetics
FD Genetics Society of America
SP 1275
OP 1280
DO 10.1534/genetics.104.027037
VO 167
IS 3
A1 Karakozova, Marina
A1 Savitskaya, Ekaterina
A1 Melnikova, Larisa
A1 Parshikov, Aleksandr
A1 Georgiev, Pavel
YR 2004
UL http://www.genetics.org/content/167/3/1275.abstract
AB Transposable element P of Drosophila melanogaster is one of the best-characterized eukaryotic transposons. Successful transposition requires the interaction between transposase complexes at both termini of the P element. Here we found that insertion of one or two copies of the Su(Hw) insulator in the P transposon reduces the frequency of its transposition. Inactivation of a Mod(mdg4) component of the Su(Hw) insulator suppresses the insulator effect. Thus, the Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells.