PT  - JOURNAL ARTICLE
AU  - Karakozova, Marina
AU  - Savitskaya, Ekaterina
AU  - Melnikova, Larisa
AU  - Parshikov, Aleksandr
AU  - Georgiev, Pavel
TI  - The Mod(mdg4) Component of the Su(Hw) Insulator Inserted in the <em>P</em> Transposon Can Repress Its Mobility in <em>Drosophila melanogaster</em>
AID  - 10.1534/genetics.104.027037
DP  - 2004 Jul 01
TA  - Genetics
PG  - 1275--1280
VI  - 167
IP  - 3
4099  - http://www.genetics.org/content/167/3/1275.short
4100  - http://www.genetics.org/content/167/3/1275.full
SO  - Genetics2004 Jul 01; 167
AB  - Transposable element P of Drosophila melanogaster is one of the best-characterized eukaryotic transposons. Successful transposition requires the interaction between transposase complexes at both termini of the P element. Here we found that insertion of one or two copies of the Su(Hw) insulator in the P transposon reduces the frequency of its transposition. Inactivation of a Mod(mdg4) component of the Su(Hw) insulator suppresses the insulator effect. Thus, the Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells.