PT - JOURNAL ARTICLE
AU - Vitalis, Renaud
AU - Couvet, Denis
TI - Estimation of Effective Population Size and Migration Rate From One- and Two-Locus Identity Measures
DP - 2001 Feb 01
TA - Genetics
PG - 911--925
VI - 157
IP - 2
4099 - http://www.genetics.org/content/157/2/911.short
4100 - http://www.genetics.org/content/157/2/911.full
SO - Genetics2001 Feb 01; 157
AB - Standard methods for inferring demographic parameters from genetic data are based mainly on one-locus theory. However, the association of genes at different loci (e.g., two-locus identity disequilibrium) may also contain some information about demographic parameters of populations. In this article, we define one- and two-locus parameters of population structure as functions of one- and two-locus probabilities for the identity in state of genes. Since these parameters are known functions of demographic parameters in an infinite island model, we develop moment-based estimators of effective population size and immigration rate from one- and two-locus parameters. We evaluate this method through simulation. Although variance and bias may be quite large, increasing the number of loci on which the estimates are derived improves the method. We simulate an infinite allele model and a K allele model of mutation. Bias and variance are smaller with increasing numbers of alleles per locus. This is, to our knowledge, the first attempt of a joint estimation of local effective population size and immigration rate.