RT Journal Article
SR Electronic
T1 Abnormal Turning Behavior in Drosophila Larvae: Identification and Molecular Analysis of <em>scribbler</em> (<em>sbb</em>)
JF Genetics
JO Genetics
FD Genetics Society of America
SP 1161
OP 1174
VO 155
IS 3
A1 Yang, Ping
A1 Shaver, Susan A.
A1 Hilliker, Arthur J.
A1 Sokolowski, Marla B.
YR 2000
UL http://www.genetics.org/content/155/3/1161.abstract
AB Our genetic dissection of behavior has isolated scribbler (sbb), a vital gene that encodes a novel protein expressed in the embryonic and larval nervous systems and in the imaginal discs. Larvae with mutations in sbb exhibit abnormally high amounts of turning behavior in the absence of food. sbb is a large gene spanning &gt;50 kb of genomic DNA with four major developmentally regulated transcripts. Transgenic rescue of scribbler behavior was demonstrated by targeting expression of a normal sbb transgene (sbb+) expressing one of the major transcripts to the nervous system. The vital function of sbb was restored by ubiquitous expression of this transgene throughout development.