PT - JOURNAL ARTICLE
AU - Ronin, Yefim I.
AU - Korol, Abraham B.
AU - Nevo, Eviatar
TI - Single- and Multiple-Trait Mapping Analysis of Linked Quantitative Trait Loci: Some Asymptotic Analytical Approximations
DP - 1999 Jan 01
TA - Genetics
PG - 387--396
VI - 151
IP - 1
4099 - http://www.genetics.org/content/151/1/387.short
4100 - http://www.genetics.org/content/151/1/387.full
SO - Genetics1999 Jan 01; 151
AB - Estimating the resolution power of mapping analysis of linked quantitative trait loci (QTL) remains a difficult problem, which has been previously addressed mainly by Monte Carlo simulations. The analytical method of evaluation of the expected LOD developed in this article spreads the “deterministic sampling approach for the case of two linked QTL for single- and two-trait analysis. Several complicated questions are addressed through this evaluation: the dependence of QTL detection power on the QTL effects, residual correlation between the traits, and the effect of epistatic interaction between the QTL for one or both traits on expected LOD (ELOD), etc. Although this method gives only an asymptotic estimation of ELOD, it allows one to get an approximate assessment of a broad spectrum of mapping situations. A good correspondence was found between the ELODs predicted by the model and LOD values averaged over Monte Carlo simulations.