PT - JOURNAL ARTICLE
AU - Beerli, Peter
AU - Felsenstein, Joseph
TI - Maximum-Likelihood Estimation of Migration Rates and Effective Population Numbers in Two Populations Using a Coalescent Approach
DP - 1999 Jun 01
TA - Genetics
PG - 763--773
VI - 152
IP - 2
4099 - http://www.genetics.org/content/152/2/763.short
4100 - http://www.genetics.org/content/152/2/763.full
SO - Genetics1999 Jun 01; 152
AB - A new method for the estimation of migration rates and effective population sizes is described. It uses a maximum-likelihood framework based on coalescence theory. The parameters are estimated by Metropolis-Hastings importance sampling. In a two-population model this method estimates four parameters: the effective population size and the immigration rate for each population relative to the mutation rate. Summarizing over loci can be done by assuming either that the mutation rate is the same for all loci or that the mutation rates are gamma distributed among loci but the same for all sites of a locus. The estimates are as good as or better than those from an optimized FST-based measure. The program is available on the World Wide Web at http://evolution.genetics.washington.edu/lamarc.html/.