PT  - JOURNAL ARTICLE
AU  - Gould, Karen A.
AU  - Dietrich, William F.
AU  - Borenstein, Natalie
AU  - Lander, Eric S.
AU  - Dove, William F.
TI  - <em>Mom1</em> is a Semi-Dominant Modifier of Intestinal Adenoma Size and Multiplicity in <em>Min</em>/+ Mice
DP  - 1996 Dec 01
TA  - Genetics
PG  - 1769--1776
VI  - 144
IP  - 4
4099  - http://www.genetics.org/content/144/4/1769.short
4100  - http://www.genetics.org/content/144/4/1769.full
SO  - Genetics1996 Dec 01; 144
AB  - The intestinal tumor multiplicity in mice heterozygous for ApcMin is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker-assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficiency of this method are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi-dominant fashion.