PT  - JOURNAL ARTICLE
AU  - Dickson, Barry J.
AU  - van der Straten, Alexandra
AU  - Domínguez, María
AU  - Hafen, Ernst
TI  - Mutations Modulating Raf Signaling in Drosophila Eye Development
DP  - 1996 Jan 01
TA  - Genetics
PG  - 163--171
VI  - 142
IP  - 1
4099  - http://www.genetics.org/content/142/1/163.short
4100  - http://www.genetics.org/content/142/1/163.full
SO  - Genetics1996 Jan 01; 142
AB  - The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue; another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.