RT Journal Article
SR Electronic
T1 A mathematical model of interference for use in constructing linkage maps from tetrad data.
JF Genetics
JO Genetics
FD Genetics Society of America
SP 597
OP 602
VO 129
IS 2
A1 King, J S
A1 Mortimer, R K
YR 1991
UL http://www.genetics.org/content/129/2/597.abstract
AB In determining genetic map distances it is necessary to infer crossover frequencies from the ratios of recombinant and parental progeny. To do this accurately, in intervals where multiple crossovers may occur, a mathematical model of chiasma interference must be assumed when mapping in organisms displaying such interference. In Saccharomyces cerevisiae the model most frequently used is that of R.W. Barratt. An alternative to this model is presented. This new model is implemented using a microcomputer and standard numerical methods. It is demonstrated to fit ranked tetrad data from Saccharomyces more closely than the Barratt model and thus generates more accurate estimates of map distances when used with two-point data. A computer program implementing the model has been developed for use in calculating map distances from tetrad data in Saccharomyces.