PT - JOURNAL ARTICLE
AU - Lande, R
AU - Price, T
TI - Genetic correlations and maternal effect coefficients obtained from offspring-parent regression.
DP - 1989 Aug 01
TA - Genetics
PG - 915--922
VI - 122
IP - 4
4099 - http://www.genetics.org/content/122/4/915.short
4100 - http://www.genetics.org/content/122/4/915.full
SO - Genetics1989 Aug 01; 122
AB - Additive genetic variances and covariances of quantitative characters are necessary to predict the evolutionary response of the mean phenotype vector in a population to natural or artificial selection. Standard formulas for estimating these parameters, from the resemblance between relatives in one or two characters at a time, are biased by natural selection on the parents and by maternal effects. We show how these biases can be removed using a multivariate analysis of offspring-parent regressions. A dynamic model of maternal effects demonstrates that, in addition to the phenotypic variance-covariance matrix of the characters, sufficient parameters for predicting the response of the mean phenotype vector to weak selection are the additive genetic variance-covariance matrix and a set of causal coefficients for maternal effects. These can be simultaneously estimated from offspring-parent regressions alone, in some cases just from the daughter-mother regressions, if all of the important selected and maternal characters have been measured and included in the analysis.