Hangnoh “Lee” is interested in how changes in genome structure can impact transcriptome. During his graduate training, he performed functional genomics studies of how transcription factor E2F and retinoblastoma tumor suppressor protein (RB) act synergistically to coordinate cell cycle progression and cell differentiation using Drosophila tissue culture cells as a model. He transitioned to studying genome structure of Drosophila as a postdoc where he performed dual roles as a molecular biologist and bioinformatician to molecularly generate and computationally analyze large-scale sequencing data of over 20 genomes and 3,000 transcriptomes. As a highlight, he processed genomic and transcriptomic data of 19 Drosophila cell lines by employing the power of Next-Generation Sequencing. His study has revealed how cell lines acquire “culturability” by adjusting gene copy number configurations.
Since his graduate training, he has been broadly trained in cell biology, molecular biology, genomics, and computational biology. His topics of expertise include the genome evolution, DNA copy number alteration, and gene dosage compensation.