Defence against infection is increasingly recognized to have a complex determination, shaped by the contributions of multiple genes and a multitude of environmental factors. While we may conventionally imagine defense against infection to be determined primarily by the activity of the host immune system, recent studies have established diverse biological mechanisms for regulating defense. The genetics of immunity is being studied using a wide variety of approaches and organisms from agriculturally relevant plants to genetic models such as Drosophila to humans.
In this spirit of greater discourse among researchers across disciplines, the journals of the Genetics Society of America — GENETICS and G3: Genes|Genomes|Genetics — invite submissions to either journal that address the broad reach and complexity of the genetics of immunity. The call for papers is ongoing as detailed in this commentary, and articles are highlighted in the Genetics of Immunity series.
The Unique Antimicrobial Recognition and Signaling Pathways in Tardigrades with a Comparison Across Ecdysozoa
Marc A. Mapalo, Kazuharu Arakawa, Caitlin M. Baker, Dennis K. Persson, Denise Mirano-Bascos, Gonzalo Giribet
G3: Genes, Genomes, Genetics March 2020 10: 1137-1148; https://doi.org/10.1534/g3.119.400734
QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health
Emily A. Beck, Mark C. Currey, Clayton M. Small, William A. Cresko
G3: Genes, Genomes, Genetics February 2020 10: 613-622; https://doi.org/10.1534/g3.119.400685
Validation and Characterization of Maize Multiple Disease Resistance QTL
Lais B. Martins, Elizabeth Rucker, Wade Thomason, Randall J. Wisser, James B. Holland, Peter Balint-Kurti
G3: Genes, Genomes, Genetics September 2019 9: 2905-2912; https://doi.org/10.1534/g3.119.400195
Unravelling the Complex Genetics of Karnal Bunt (Tilletia indica) Resistance in Common Wheat (Triticum aestivum) by Genetic Linkage and Genome-Wide Association Analyses
Livinus Emebiri, Sukhwinder Singh, Mui-Keng Tan, Pawan K. Singh, Guillermo Fuentes-Dávila, Francis Ogbonnaya
G3: Genes, Genomes, Genetics May 2019 9: 1437-1447; https://doi.org/10.1534/g3.119.400103
Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14
Daniel E. Miller, Carmy Forney, Mark Rochman, Stacey Cranert, Jeffery Habel, Jeffrey Rymer, Arthur Lynch, Connor Schroeder, Josh Lee, Amber Sauder, Quinton Smith, Mehak Chawla, Michael P. Trimarchi, Xiaoming Lu, Ellen Fjellman, Michael Brusilovsky, Artem Barski, Stephen Waggoner, Matthew T. Weirauch, Marc E. Rothenberg, Leah C. Kottyan
G3: Genes, Genomes, Genetics March 2019 9: 729-736; https://doi.org/10.1534/g3.118.200901
A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting in Drosophila Follicular Somatic Cells
Nelson Martins, Aurélie Lemoine, Estelle Santiago, Simona Paro, Jean-Luc Imler, Carine Meignin
G3: Genes, Genomes, Genetics February 2019 9: 403-412; https://doi.org/10.1534/g3.118.200872
A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species
Ilias Kounatidis, Lauren Ames, Rupal Mistry, Hsueh-lui Ho, Ken Haynes, Petros Ligoxygakis
G3: Genes, Genomes, Genetics May 2018 8: 1637-1647; https://doi.org/10.1534/g3.118.200182
Tools Allowing Independent Visualization and Genetic Manipulation of Drosophila melanogaster Macrophages and Surrounding Tissues
Attila Gyoergy, Marko Roblek, Aparna Ratheesh, Katarina Valoskova, Vera Belyaeva, Stephanie Wachner, Yutaka Matsubayashi, Besaiz J. Sánchez-Sánchez, Brian Stramer, Daria E. Siekhaus
G3: Genes, Genomes, Genetics March 2018 8: 845-857; https://doi.org/10.1534/g3.117.300452
MicroRNAs That Contribute to Coordinating the Immune Response in Drosophila melanogaster
Magda L. Atilano, Marcus Glittenberg, Annabel Monteiro, Richard R. Copley and Petros Ligoxygakis
Genetics September 1, 2017 vol. 207 no. 1 163-178; https://doi.org/10.1534/genetics.116.196584
Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection Open Access
Chuan Cao, Rodrigo Cogni, Vincent Barbier, Francis M. Jiggins
Genetics August 2017 206: 2159-2173; https://doi.org/10.1534/genetics.117.201970
The Immune Phenotype of Three Drosophila Leukemia Models
Badrul Arefin, Martin Kunc, Robert Krautz, Ulrich Theopold
G3: Genes, Genomes, Genetics July 2017 7: 2139-2149; https://doi.org/10.1534/g3.117.039487
Genome-Wide Exome Analysis of Cmv5-Disparate Mouse Strains that Differ in Host Resistance to Murine Cytomegalovirus Infection
Alyssa Gillespie, Heather Lee, Catherine Robertson, Maya Cabot, Michael G. Brown
G3: Genes, Genomes, Genetics June 2017 7: 1979-1984; https://doi.org/10.1534/g3.117.042531
Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota in Drosophila melanogaster
Rupal Mistry, Ilias Kounatidis, Petros Ligoxygakis
Genetics June 2017 206: 889-904; https://doi.org/10.1534/genetics.116.190215
A Phylogenetic Codon Substitution Model for Antibody Lineages Open Access
Kenneth B. Hoehn, Gerton Lunter, Oliver G. Pybus
Genetics May 2017 206: 417-427; https://doi.org/10.1534/genetics.116.196303
Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like
Lauren Forbes-Beadle, Tova Crossman, Travis K. Johnson, Richard Burke, Coral G. Warr, and James C. Whisstock
GENETICS 2016; 204: 675-681.
Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host
Michael R. Botts, Lianne B. Cohen, Christopher S. Probert, Fengting Wu, and Emily R. Troemel
G3 2016; 6: 2707-2716.
Genetics Effector-Triggered Immune Response in Arabidopsis thaliana Is a Quantitative Trait
Michail Iakovidis, Paulo J. P. L. Teixeira, Moises Exposito-Alonso, Matthew G. Cowper, Theresa F. Law, Qingli Liu, Minh Chau Vu, Troy Minh Dang, Jason A. Corwin, Detlef Weigel, Jeffery L. Dangl, and Sarah R. Grant
GENETICS 2016; 204: 337-353.
Genetic Architecture of Resistance to Stripe Rust in a Global Winter Wheat Germplasm Collection
Peter Bulli, Junli Zhang, Shiaoman Chao, Xianming Chen, and Michael Pumphrey
G3 2016; 6: 2237-2253.
Genomic Signatures of Experimental Adaptation to Antimicrobial Peptides in Staphylococcus aureus
Paul R. Johnston, Adam J. Dobson, and Jens Rolff
G3 2016; 6: 1535-1539.
Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus
Lu Liu, Xianyong Yin, Leilei Wen, Chao Yang, Yujun Sheng, Yan Lin, Zhengwei Zhu, Changbing Shen, Yinjuan Shi, Yajie Zheng, Sen Yang, Xuejun Zhang, and Yong Cui
G3 2016; 6: 1503-1511.
Drosophila melanogaster Natural Variation Affects Growth Dynamics of Infecting Listeria monocytogenes
Alejandra Guzmán Hotson and David S. Schneider
G3 2015; 5: 2593-2600.
Persistent Activation of the Innate Immune Response in Adult Drosophila Following Radiation Exposure During Larval Development
Lisa J. Sudmeier, Sai-Suma Samudrala, Steven P. Howard, and Barry Ganetzky
G3 2015; 5: 2299-2306.
Association Mapping of Disease Resistance Traits in Rainbow Trout Using Restriction Site Associated DNA Sequencing
Nathan R. Campbell, Scott E. LaPatra, Ken Overturf, Richard Towner, and Shawn R. Narum
G3 2014; 4: 2473-2481.
Genetics Unraveling Genomic Complexity at a Quantitative Disease Resistance Locus in Maize
Tiffany M. Jamann, Jesse A. Poland, Judith M. Kolkman, Laurie G. Smith, and Rebecca J. Nelson
GENETICS 2014; 198: 333-344.
Fighting a Losing Battle: Vigorous Immune Response Countered by Pathogen Suppression of Host Defenses in the Chytridiomycosis-Susceptible Frog Atelopus zeteki
Amy R. Ellison, Anna E. Savage, Grace V. DiRenzo, Penny Langhammer, Karen R. Lips, and Kelly R. Zamudio
G3 2014; 4: 1275-1289.
Inducible Defenses Stay Up Late: Temporal Patterns of Immune Gene Expression in Tenebrio molitor
Paul R Johnston, Olga Makarova, and Jens Rolff
G3 2014; 4: 947-955.
Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
Fatuma-Said Muhali, Tian-tian Cai, Jiao-li Zhu, Qiu Qin, Jian Xu, Shuang-tao He, Xiao-hong Shi, Wen-juan Jiang, Ling Xiao, Dan-Feng Li, and Jin-an Zhang
G3 2014; 4: 973-977.
MicroRNA Regulation of Bovine Monocyte Inflammatory and Metabolic Networks in an In Vivo Infection Model
Nathan Lawless, Timothy A. Reinhardt, Kenneth Bryan, Mike Baker, Bruce Pesch, Duane Zimmerman, Kurt Zuelke, Tad Sonstegard, Cliona O’Farrelly, John D. Lippolis, and David J. Lynn
G3 2014; 4: 957-971.
The Genetics of Immunity
Brian P. Lazzaro and David S. Schneider
GENETICS 2014; 197: 467-470. [Full text] [PDF]
An Unexpected Link Between Notch Signaling and ROS in Restricting the Differentiation of Hematopoietic Progenitors in Drosophila
Chiyedza Small, Johnny Ramroop, Maria Otazo, Lawrence H. Huang, Shireen Saleque, and Shubha Govind
GENETICS 2014; 197: 471-483.
Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity
Lesly De Arras, Rebecca Laws, Sonia M. Leach, Kyle Pontis, Jonathan H. Freedman, David A. Schwartz, and Scott Alper
GENETICS 2014; 197: 485-496.
Domain Specificity of MAP3K Family Members, MLK and Tak1, for JNK Signaling in Drosophila
Beth Stronach, Ashley L. Lennox, and Rebecca A. Garlena
GENETICS 2014; 197: 497-513.
The SKPO-1 Peroxidase Functions in the Hypodermis to Protect Caenorhabditis elegans From Bacterial Infection
George R. Tiller and Danielle A. Garsin
GENETICS 2014; 197: 515-526.
Regulation of Toll Signaling and Inflammation by β-Arrestin and the SUMO Protease Ulp1
Saima G. Anjum, Wenjian Xu, Niusha Nikkholgh, Sukanya Basu, Yingchao Nie, Mary Thomas, Mridula Satyamurti, Bogdan A. Budnik, Y. Tony Ip, and Alexey Veraksa
GENETICS 2013; 195: 1307-1317.
A Genome-Wide Association Study Reveals Genes Associated with Fusarium Ear Rot Resistance in a Maize Core Diversity Panel
Charles T. Zila, L. Fernando Samayoa, Rogelio Santiago, Ana Butrón, and James B. Holland
G3 2013; 3: 2095-2104.
Fine-Scale Analysis of Parasite Resistance Genes in the Red Flour Beetle, Tribolium castaneum
Daibin Zhong, Aditi Pai, Mei-Hui Wang, Naomi Keech, and Guiyun Yan
GENETICS 2013; 195: 253-261.
Major Histocompatibility Complex Class I Haplotype Diversity in Chinese Rhesus Macaques
Julie A. Karl, Patrick S. Bohn, Roger W. Wiseman, Francesca A. Nimityongskul, Simon M. Lank, Gabriel J. Starrett, and David H. O’Connor
G3 2013; 3: 1195-1201.
Genetic Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell Traits in African-Americans: An Electronic Medical Record-based Genome-Wide Association Study
Keyue Ding, Mariza de Andrade, Teri A. Manolio, Dana C. Crawford, Laura J. Rasmussen-Torvik, Marylyn D. Ritchie, Joshua C. Denny, Daniel R. Masys, Hayan Jouni, Jennifer A. Pachecho, Abel N. Kho, Dan M. Roden, Rex Chisholm, and Iftikhar J. Kullo
G3 2013; 3: 1061-1068.
Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa
Khalid Moumad, Jesus Lascorz, Melanie Bevier, Meriem Khyatti, Moulay Mustapha Ennaji, Abdellatif Benider, Stefanie Huhn, Shun Lu, Lotfi Chouchane, Marilys Corbex, Kari Hemminki, and Asta Försti
G3 2013; 3: 971-977.
Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene
Sarah Connell, Kieran G. Meade, Brenda Allan, Andrew T. Lloyd, Tim Downing, Cliona O’Farrelly, and Daniel G. Bradley
G3 2013; 3: 881-890.
Reproductive Status Alters Transcriptomic Response to Infection in Female Drosophila melanogaster
Sarah M. Short and Brian P. Lazzaro
G3 2013; 3: 827-840.
The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in a Drosophila Model of Ataxia-Telangiectasia
Andrew J. Petersen, Rebeccah J. Katzenberger, and David A. Wassarman
GENETICS 2013; 194: 133-142.
Engineering Silkworms for Resistance to Baculovirus Through Multigene RNA Interference
Edupalli V. Subbaiah, Corinne Royer, Sriramana Kanginakudru, Valluri V. Satyavathi, Adari Sobhan Babu, Vankadara Sivaprasad, Gérard Chavancy, Martine DaRocha, Audrey Jalabert, Bernard Mauchamp, Ibrahim Basha, Pierre Couble, and Javaregowda Nagaraju
GENETICS 2013; 193: 63-75.
Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis
Tashauna M. Felix, Kimberly A. Hughes, Eric A. Stone, Jenny M. Drnevich, and Jeff Leips
GENETICS 2012; 191: 989-1002.