August 2020 Cover Image

Cytoskeleton genes are responsible for forming the structural (architectural) components of cells and have expanded into multigene families in humans relative to earlier ancestors. In this issue, Garge and colleagues studied the evolutionary divergence of such duplicated genes by “humanizing” yeast, replacing yeast cytoskeletal genes with different versions of the corresponding human genes. This is symbolized in the image by human workers constructing yeast from the inside out, as inspired by Fernand Léger's “The Builders” and illustrated by Ella Marushchenko. See Garge et al., pp. 1153–1169.