Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

J. Graham Ruby; Kevin M. Wright; Kristin A. Rand; Amir Kermany; Keith Noto; Don Curtis; Neal Varner; Daniel Garrigan; Dmitri Slinkov; Ilya Dorfman; Julie M. Granka; Jake Byrnes; Natalie Myres; Catherine Ball

doi:10.1534/genetics.118.301613

Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

J. Graham Ruby, Kevin M. Wright, Kristin A. Rand, Amir Kermany, Keith Noto, Don Curtis, Neal Varner, Daniel Garrigan, Dmitri Slinkov, Ilya Dorfman, Julie M. Granka, Jake Byrnes, Natalie Myres and Catherine Ball

Genetics November 1, 2018 vol. 210 no. 3 1109-1124; https://doi.org/10.1534/genetics.118.301613

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J. Graham Ruby

*Calico Life Sciences LLC, South San Francisco, California 94080

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For correspondence: graham@calicolabs.com cball@ancestry.com

Kevin M. Wright

*Calico Life Sciences LLC, South San Francisco, California 94080

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Kristin A. Rand

†Ancestry, San Francisco, California 94107

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Amir Kermany

†Ancestry, San Francisco, California 94107

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Keith Noto

†Ancestry, San Francisco, California 94107

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Don Curtis

‡Ancestry, Lehi, Utah 84043

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Neal Varner

‡Ancestry, Lehi, Utah 84043

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Daniel Garrigan

†Ancestry, San Francisco, California 94107

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Dmitri Slinkov

‡Ancestry, Lehi, Utah 84043

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Ilya Dorfman

†Ancestry, San Francisco, California 94107

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Julie M. Granka

†Ancestry, San Francisco, California 94107

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Jake Byrnes

†Ancestry, San Francisco, California 94107

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Natalie Myres

‡Ancestry, Lehi, Utah 84043

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Catherine Ball

†Ancestry, San Francisco, California 94107

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For correspondence: graham@calicolabs.com cball@ancestry.com

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Supplemental material available at Figshare: https://doi.org/10.25386/genetics.7108637

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Volume 210 Issue 3, November 2018

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Population and evolutionary genetics

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Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

Genetics November 1, 2018 vol. 210 no. 3 1109-1124; https://doi.org/10.1534/genetics.118.301613

Open Access

J. Graham Ruby

*Calico Life Sciences LLC, South San Francisco, California 94080

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For correspondence: graham@calicolabs.com cball@ancestry.com

Kevin M. Wright

*Calico Life Sciences LLC, South San Francisco, California 94080

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Kristin A. Rand

†Ancestry, San Francisco, California 94107

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Amir Kermany

†Ancestry, San Francisco, California 94107

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Keith Noto

†Ancestry, San Francisco, California 94107

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Don Curtis

‡Ancestry, Lehi, Utah 84043

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Neal Varner

‡Ancestry, Lehi, Utah 84043

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Daniel Garrigan

†Ancestry, San Francisco, California 94107

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Dmitri Slinkov

‡Ancestry, Lehi, Utah 84043

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Ilya Dorfman

†Ancestry, San Francisco, California 94107

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Julie M. Granka

†Ancestry, San Francisco, California 94107

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Jake Byrnes

†Ancestry, San Francisco, California 94107

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Natalie Myres

‡Ancestry, Lehi, Utah 84043

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Catherine Ball

†Ancestry, San Francisco, California 94107

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For correspondence: graham@calicolabs.com cball@ancestry.com

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Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

Genetics November 1, 2018 vol. 210 no. 3 1109-1124; https://doi.org/10.1534/genetics.118.301613

Open Access

J. Graham Ruby

*Calico Life Sciences LLC, South San Francisco, California 94080

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For correspondence: graham@calicolabs.com cball@ancestry.com

Kevin M. Wright

*Calico Life Sciences LLC, South San Francisco, California 94080

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Kristin A. Rand

†Ancestry, San Francisco, California 94107

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Amir Kermany

†Ancestry, San Francisco, California 94107

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Keith Noto

†Ancestry, San Francisco, California 94107

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Don Curtis

‡Ancestry, Lehi, Utah 84043

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Neal Varner

‡Ancestry, Lehi, Utah 84043

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Daniel Garrigan

†Ancestry, San Francisco, California 94107

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Dmitri Slinkov

‡Ancestry, Lehi, Utah 84043

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Ilya Dorfman

†Ancestry, San Francisco, California 94107

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Julie M. Granka

†Ancestry, San Francisco, California 94107

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Jake Byrnes

†Ancestry, San Francisco, California 94107

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Natalie Myres

‡Ancestry, Lehi, Utah 84043

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Catherine Ball

†Ancestry, San Francisco, California 94107

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For correspondence: graham@calicolabs.com cball@ancestry.com

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Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

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Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

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