Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data

Chloe Robins; Allan F. McRae; Joseph E. Powell; Howard W. Wiener; Stella Aslibekyan; Elizabeth M. Kennedy; Devin M. Absher; Donna K. Arnett; Grant W. Montgomery; Peter M. Visscher; David J. Cutler; Karen N. Conneely

doi:10.1534/genetics.117.300217

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data

View ORCID ProfileChloe Robins, View ORCID ProfileAllan F. McRae, View ORCID ProfileJoseph E. Powell, Howard W. Wiener, Stella Aslibekyan, View ORCID ProfileElizabeth M. Kennedy, Devin M. Absher, View ORCID ProfileDonna K. Arnett, View ORCID ProfileGrant W. Montgomery, View ORCID ProfilePeter M. Visscher, David J. Cutler and Karen N. Conneely

Genetics December 1, 2017 vol. 207 no. 4 1547-1560; https://doi.org/10.1534/genetics.117.300217

Chloe Robins

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

†Graduate Program in Population Biology, Ecology, and Evolution, Laney Graduate School, Emory University, Atlanta, Georgia 30322

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ORCID record for Chloe Robins
For correspondence: crobi27@emory.edu

Allan F. McRae

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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ORCID record for Allan F. McRae

Joseph E. Powell

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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Howard W. Wiener

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Stella Aslibekyan

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Elizabeth M. Kennedy

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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ORCID record for Elizabeth M. Kennedy

Devin M. Absher

††HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806

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Donna K. Arnett

‡‡College of Public Health, University of Kentucky, Lexington, Kentucky 40536

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Grant W. Montgomery

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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Peter M. Visscher

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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David J. Cutler

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Karen N. Conneely

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Volume 207 Issue 4, December 2017

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Population and evolutionary genetics

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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data

Genetics December 1, 2017 vol. 207 no. 4 1547-1560; https://doi.org/10.1534/genetics.117.300217

Chloe Robins

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

†Graduate Program in Population Biology, Ecology, and Evolution, Laney Graduate School, Emory University, Atlanta, Georgia 30322

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ORCID record for Chloe Robins
For correspondence: crobi27@emory.edu

Allan F. McRae

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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ORCID record for Allan F. McRae

Joseph E. Powell

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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Howard W. Wiener

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Stella Aslibekyan

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Elizabeth M. Kennedy

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Devin M. Absher

††HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806

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Donna K. Arnett

‡‡College of Public Health, University of Kentucky, Lexington, Kentucky 40536

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ORCID record for Donna K. Arnett

Grant W. Montgomery

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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Peter M. Visscher

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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David J. Cutler

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Karen N. Conneely

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data

Genetics December 1, 2017 vol. 207 no. 4 1547-1560; https://doi.org/10.1534/genetics.117.300217

Chloe Robins

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

†Graduate Program in Population Biology, Ecology, and Evolution, Laney Graduate School, Emory University, Atlanta, Georgia 30322

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ORCID record for Chloe Robins
For correspondence: crobi27@emory.edu

Allan F. McRae

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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ORCID record for Allan F. McRae

Joseph E. Powell

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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ORCID record for Joseph E. Powell

Howard W. Wiener

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Stella Aslibekyan

**Department of Epidemiology, University of Alabama at Birmingham, Alabama 35205 and

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Elizabeth M. Kennedy

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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ORCID record for Elizabeth M. Kennedy

Devin M. Absher

††HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806

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Donna K. Arnett

‡‡College of Public Health, University of Kentucky, Lexington, Kentucky 40536

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ORCID record for Donna K. Arnett

Grant W. Montgomery

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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ORCID record for Grant W. Montgomery

Peter M. Visscher

‡The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

§The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia

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ORCID record for Peter M. Visscher

David J. Cutler

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Karen N. Conneely

*Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322

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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data

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