Inferring Heterozygosity from Ancient and Low Coverage Genomes

Athanasios Kousathanas; Christoph Leuenberger; Vivian Link; Christian Sell; Joachim Burger; Daniel Wegmann

doi:10.1534/genetics.116.189985

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Inferring Heterozygosity from Ancient and Low Coverage Genomes

Athanasios Kousathanas, Christoph Leuenberger, Vivian Link, Christian Sell, Joachim Burger and Daniel Wegmann

Genetics January 1, 2017 vol. 205 no. 1 317-332; https://doi.org/10.1534/genetics.116.189985

Open Access

Athanasios Kousathanas

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christoph Leuenberger

‡Department of Mathematics, University of Fribourg, 1200, Switzerland

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Vivian Link

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christian Sell

§Paleogenetics Group, University of Mainz, 55122, Germany

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Joachim Burger

§Paleogenetics Group, University of Mainz, 55122, Germany

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Daniel Wegmann

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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For correspondence: daniel.wegmann@unifr.ch

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Supporting Information

Figure S1 - Post-mortem damage pattern profiles of ancient samples. (.pdf, 149 KB)
Figure S2 - Effect of Recalibration on Quality Scores. (.pdf, 104 KB)

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Volume 205 Issue 1, January 2017

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Population and evolutionary genetics

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Inferring Heterozygosity from Ancient and Low Coverage Genomes

Athanasios Kousathanas, Christoph Leuenberger, Vivian Link, Christian Sell, Joachim Burger and Daniel Wegmann

Genetics January 1, 2017 vol. 205 no. 1 317-332; https://doi.org/10.1534/genetics.116.189985

Open Access

Athanasios Kousathanas

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christoph Leuenberger

‡Department of Mathematics, University of Fribourg, 1200, Switzerland

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Vivian Link

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christian Sell

§Paleogenetics Group, University of Mainz, 55122, Germany

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Joachim Burger

§Paleogenetics Group, University of Mainz, 55122, Germany

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Daniel Wegmann

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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For correspondence: daniel.wegmann@unifr.ch

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Inferring Heterozygosity from Ancient and Low Coverage Genomes

Athanasios Kousathanas, Christoph Leuenberger, Vivian Link, Christian Sell, Joachim Burger and Daniel Wegmann

Genetics January 1, 2017 vol. 205 no. 1 317-332; https://doi.org/10.1534/genetics.116.189985

Open Access

Athanasios Kousathanas

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christoph Leuenberger

‡Department of Mathematics, University of Fribourg, 1200, Switzerland

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Vivian Link

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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Christian Sell

§Paleogenetics Group, University of Mainz, 55122, Germany

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Joachim Burger

§Paleogenetics Group, University of Mainz, 55122, Germany

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Daniel Wegmann

*Department of Biology and Biochemistry, University of Fribourg, 1700, Switzerland

†Statistical and Computational Evolutionary Biology Group, Swiss Institute of Bioinformatics, Fribourg, 1700, Switzerland

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For correspondence: daniel.wegmann@unifr.ch

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