Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

J. Sidney Ang; Supipi Duffy; Romulo Segovia; Peter C. Stirling; Philip Hieter

doi:10.1534/genetics.116.192211

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

J. Sidney Ang, Supipi Duffy, Romulo Segovia, Peter C. Stirling and Philip Hieter

Genetics November 1, 2016 vol. 204 no. 3 975-986; https://doi.org/10.1534/genetics.116.192211

J. Sidney Ang

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Supipi Duffy

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Romulo Segovia

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Peter C. Stirling

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Philip Hieter

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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For correspondence: hieter@msl.ubc.ca

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Supporting Information

Figure S1 - Positional effects of the dMutator phenotype. (.pdf, 696 KB)
Table S1 - DNA helicases tested for dMutator phenotype. (.xlsx, 40 KB)
Table S2 - Yeast strains and plasmids used in this study. (.xlsx, 38 KB)

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Volume 204 Issue 3, November 2016

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Genome integrity and transmission

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

J. Sidney Ang, Supipi Duffy, Romulo Segovia, Peter C. Stirling and Philip Hieter

Genetics November 1, 2016 vol. 204 no. 3 975-986; https://doi.org/10.1534/genetics.116.192211

J. Sidney Ang

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Supipi Duffy

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Romulo Segovia

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Peter C. Stirling

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Philip Hieter

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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For correspondence: hieter@msl.ubc.ca

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

J. Sidney Ang, Supipi Duffy, Romulo Segovia, Peter C. Stirling and Philip Hieter

Genetics November 1, 2016 vol. 204 no. 3 975-986; https://doi.org/10.1534/genetics.116.192211

J. Sidney Ang

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Search for this author on this site

Supipi Duffy

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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Romulo Segovia

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Peter C. Stirling

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada

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Philip Hieter

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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For correspondence: hieter@msl.ubc.ca

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

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