Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation

Jirong Wang; Chaojun Wang; Chengyun Xu; Xiaokai Wu; Dun Hong; Wei Shi; Ying Gong; Haixiao Chen; Fanxin Long; Ximei Wu

doi:10.1534/genetics.115.180109

Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation

Jirong Wang, Chaojun Wang, Chengyun Xu, Xiaokai Wu, Dun Hong, Wei Shi, Ying Gong, Haixiao Chen, Fanxin Long and Ximei Wu

Genetics March 1, 2016 vol. 202 no. 3 1055-1069; https://doi.org/10.1534/genetics.115.180109

Jirong Wang

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Chaojun Wang

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Chengyun Xu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Xiaokai Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Dun Hong

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Wei Shi

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Ying Gong

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Haixiao Chen

‡Department of Orthopedics, Taizhou Hospital, Linhai 317000, China

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Fanxin Long

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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Ximei Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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For correspondence: xiwu@zju.edu.cn

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Data supplements

Supporting Information for Wang et al., 2016

Supporting Information

Figure S1 - Cdc42 mutants have severe skeletal defects. (.pptx, 428 KB)
Table S1 - Oligonucleotide sequences for lentivirally expressing shRNA used in this study. (.pptx, 32 KB)
Table S2 - Sequences of siRNA used in this study. (.pptx, 35 KB)
Table S3 - Listing of primers used for qPCR in this study. (.docx, 27 KB)

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Volume 202 Issue 3, March 2016

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Developmental and behavioral genetics

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Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation

Jirong Wang, Chaojun Wang, Chengyun Xu, Xiaokai Wu, Dun Hong, Wei Shi, Ying Gong, Haixiao Chen, Fanxin Long and Ximei Wu

Genetics March 1, 2016 vol. 202 no. 3 1055-1069; https://doi.org/10.1534/genetics.115.180109

Jirong Wang

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Chaojun Wang

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Chengyun Xu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Xiaokai Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Dun Hong

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Wei Shi

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Ying Gong

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Haixiao Chen

‡Department of Orthopedics, Taizhou Hospital, Linhai 317000, China

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Fanxin Long

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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Ximei Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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For correspondence: xiwu@zju.edu.cn

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Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation

Jirong Wang, Chaojun Wang, Chengyun Xu, Xiaokai Wu, Dun Hong, Wei Shi, Ying Gong, Haixiao Chen, Fanxin Long and Ximei Wu

Genetics March 1, 2016 vol. 202 no. 3 1055-1069; https://doi.org/10.1534/genetics.115.180109

Jirong Wang

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Chaojun Wang

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Chengyun Xu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Xiaokai Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Dun Hong

†Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

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Wei Shi

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Ying Gong

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

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Haixiao Chen

‡Department of Orthopedics, Taizhou Hospital, Linhai 317000, China

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Fanxin Long

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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Ximei Wu

*Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China

§Departments of Orthopaedic Surgery, Medicine and Developmental Biology, Washington University, St. Louis, Missouri 63110

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For correspondence: xiwu@zju.edu.cn

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