Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster
Audrey Chen, Fanny Ng, Tim Lebestky, Anna Grygoruk, Christine Djapri, Hakeem O. Lawal, Harshul A. Zaveri, Filmon Mehanzel, Rod Najibi, Gabriel Seidman, Niall P. Murphy, Rachel L. Kelly, Larry C. Ackerson, Nigel T. Maidment, F. Rob Jackson and David E. Krantz
Genetics January 1, 2013 vol. 193 no. 1 159-176; https://doi.org/10.1534/genetics.112.142042
Audrey Chen
*Department of Neurobiology, University of California, Los Angeles, California 90095
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Fanny Ng
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
Tim Lebestky
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Anna Grygoruk
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Christine Djapri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Hakeem O. Lawal
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Harshul A. Zaveri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Filmon Mehanzel
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rod Najibi
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Gabriel Seidman
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Niall P. Murphy
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rachel L. Kelly
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Larry C. Ackerson
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Nigel T. Maidment
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
F. Rob Jackson
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
David E. Krantz
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Data supplements
Files in this data supplement:
- Supporting Information: Figures S1-S7 (PDF, 1.3 MB)
- Figure S1: Protein expression and neurotransmitter content in genetically rescued dVMAT mutants. (PDF, 96 KB)
- Figure S2: Aminergic cell counts in dVMAT mutants. (PDF, 439 KB)
- Figure S3: Homozygous survival plotted as a function of population density, and with dVMAT mutants expressing UAS-DVMAT using the indicated drivers. (PDF, 202 KB)
- Figure S4: Expression of UAS-DVMAT using Ddc-Gal4 does not rescue larval locomotion deficits of the dVMAT mutant. (PDF, 60 KB)
- Figure S5: Controls for locomotion assays. (PDF, 105 KB)
- Figure S6: Octopamine partially rescues egg-laying. (PDF, 55 KB)
- Figure S7: Average LD activity profiles for the dVMAT mutant and rescue lines. (PDF, 543 KB)
PUBLICATION INFORMATION
ARTICLE CLASSIFICATION
Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster
Audrey Chen, Fanny Ng, Tim Lebestky, Anna Grygoruk, Christine Djapri, Hakeem O. Lawal, Harshul A. Zaveri, Filmon Mehanzel, Rod Najibi, Gabriel Seidman, Niall P. Murphy, Rachel L. Kelly, Larry C. Ackerson, Nigel T. Maidment, F. Rob Jackson and David E. Krantz
Genetics January 1, 2013 vol. 193 no. 1 159-176; https://doi.org/10.1534/genetics.112.142042
Audrey Chen
*Department of Neurobiology, University of California, Los Angeles, California 90095
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Fanny Ng
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
Tim Lebestky
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Anna Grygoruk
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Christine Djapri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Hakeem O. Lawal
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Harshul A. Zaveri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Filmon Mehanzel
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rod Najibi
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Gabriel Seidman
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Niall P. Murphy
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rachel L. Kelly
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Larry C. Ackerson
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Nigel T. Maidment
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
F. Rob Jackson
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
David E. Krantz
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster
Audrey Chen, Fanny Ng, Tim Lebestky, Anna Grygoruk, Christine Djapri, Hakeem O. Lawal, Harshul A. Zaveri, Filmon Mehanzel, Rod Najibi, Gabriel Seidman, Niall P. Murphy, Rachel L. Kelly, Larry C. Ackerson, Nigel T. Maidment, F. Rob Jackson and David E. Krantz
Genetics January 1, 2013 vol. 193 no. 1 159-176; https://doi.org/10.1534/genetics.112.142042
Audrey Chen
*Department of Neurobiology, University of California, Los Angeles, California 90095
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Fanny Ng
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
Tim Lebestky
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Anna Grygoruk
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Christine Djapri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Hakeem O. Lawal
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Harshul A. Zaveri
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Filmon Mehanzel
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rod Najibi
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Gabriel Seidman
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Niall P. Murphy
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Rachel L. Kelly
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Larry C. Ackerson
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Nigel T. Maidment
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
F. Rob Jackson
‡Department of Neuroscience, Tufts Center for Neuroscience Research, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111
David E. Krantz
†Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095