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Bayesian Clustering Using Hidden Markov Random Fields in Spatial Population Genetics

Olivier François, Sophie Ancelet and Gilles Guillot
Genetics October 1, 2006 vol. 174 no. 2 805-816; https://doi.org/10.1534/genetics.106.059923
Olivier François
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Sophie Ancelet
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Gilles Guillot
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  • Figure 1.—
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    Figure 1.—

    Two cluster configurations from the three-states Potts–Dirichlet model. For ψ = 0.1, no spatial structure can be observed (the situation is close to the noninformative prior used by STRUCTURE). For ψ = 0.9, a number of nonnecessarily connected random clusters can be observed.

  • Figure 2.—
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    Figure 2.—

    Distributions of the number of clusters estimated by the HRMF model. Data sets were simulated from the prior distributions of the HMRF model. The vertical lines indicate the true number of populations.

  • Figure 3.—
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    Figure 3.—

    Estimated cluster configuration for the Scandinavian brown bear data set in North Sweden using the HMRF model (four clusters).

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    Figure 4.—

    Sampled geographical coordinates of 70 individuals from the Pakistan data set and the associated Dirichlet tiling. (The full sample was not shown but a similar spatial distribution was assumed for the 200 individuals.)

  • Figure 5.—
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    Figure 5.—

    The reconciliation illustrated. At the left of the ψ-axis, a clustering analysis does not account for the spatial continuity of allele frequencies and may detect more clusters than actually exist. At the right, the pure continuity hypothesis assumes no cluster. Here the vision is intermediate, with the main discontinuities confirmed, but some small clusters may be considered nonsignificant.

Tables

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  • TABLE 1

    Proportions of individuals assigned to extra clusters given the number of estimated clusters Embedded Image and their true number K

    Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
    True K = 100.02000
    True K = 2—00.0136—0.03
    True K = 3——00.00960.0267
    • — indicates cases that never occurred during the simulation study.

  • TABLE 2

    Error rate in coassignments (ERCA) for 200 simulated data sets (n = 100, L = 10, J𝓁 = 10) with Kmax = 2

    Genetic structure:Spatial structure:Inbreeding
    FSTψ(ϕ1, ϕ2)Nonspatial modelHMRF modelGENELAND
    AllAllAll16.10.73.2
    FST ≤ 0.08AllAll26.31.66.6
    0.08 < FST ≤ 0.09AllAll7.60.61.4
    0.09 < FST ≤ 0.1AllAll80.61.4
    FST > 0.1AllAll8.30.21.1
    Allψ ≤ 0.2All1.111.1
    All0.2 < ψ ≤ 0.4All10.81.6
    All0.4 < ψ ≤ 0.6All2.70.70.9
    All0.6 < ψ ≤ 0.8All28.20.44.7
    Allψ > 0.8All42.40.56.9
    AllAll(<0.06, <0.06)17.20.30.7
    AllAll(<0.06, >0.1) or (>0.1, <0.06)100.51.9
    AllAll(>0.1, >0.1)12.311.5
    FST ≤ 0.08ψ ≤ 0.4All2.72.12.8
    FST ≤ 0.080.6 < ψ ≤ 1All41.80.99.4
    FST > 0.1ψ ≤ 0.4All0.20.10.4
    FST > 0.10.6 < ψ ≤ 1All23.70.32.4
    • The three models were initialized at Kmax = 2.

  • TABLE 3

    Latitudes and longitudes for the eight Pakistan samples (from Cann et al. 2002)

    Sample nameLatitudeLongitudeSample size
    Brahui30°–31° N66°–67° E25
    Balochi30°–31° N66°–67° E25
    Hazara33°–34° N70° E25
    Makrani26° N62°–66° E25
    Shindi24°–27° N68°–70° E25
    Pathan32°–35° N69°–72° E25
    Kalash35°–37° N71°–72° E25
    Burusho36°–37° N73°–75° E25
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Volume 174 Issue 2, October 2006

Genetics: 174 (2)

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Population and evolutionary genetics
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Bayesian Clustering Using Hidden Markov Random Fields in Spatial Population Genetics

Olivier François, Sophie Ancelet and Gilles Guillot
Genetics October 1, 2006 vol. 174 no. 2 805-816; https://doi.org/10.1534/genetics.106.059923
Olivier François
  • Find this author on Google Scholar
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  • Search for this author on this site
Sophie Ancelet
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Gilles Guillot
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Citation

Bayesian Clustering Using Hidden Markov Random Fields in Spatial Population Genetics

Olivier François, Sophie Ancelet and Gilles Guillot
Genetics October 1, 2006 vol. 174 no. 2 805-816; https://doi.org/10.1534/genetics.106.059923
Olivier François
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sophie Ancelet
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gilles Guillot
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

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Show more Investigations
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  • Article
    • Abstract
    • THE POTTS–DIRICHLET MODEL
    • HIERARCHICAL BAYES
    • SIMULATION STUDY
    • REAL DATA ANALYSIS
    • DISCUSSION
    • APPENDIX: DETAILS OF MARKOV CHAIN MONTE CARLO COMPUTATIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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