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A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

Thomas P. Neufeld, Amy H. Tang and Gerald M. Rubin
Genetics January 1, 1998 vol. 148 no. 1 277-286
Thomas P. Neufeld
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Amy H. Tang
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Gerald M. Rubin
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  • For correspondence: gerry@fruitfly.berkeley.edu
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Abstract

Specification of the R7 photoreceptor cell in the developing Drosophila eye requires the seven in absentia (sina) gene. We demonstrate that ectopic expression of sina in all cells behind the morphogenetic furrow disrupts normal eye development during pupation, resulting in a severely disorganized adult eye. Earlier events of cell fate specification appear unaffected. A genetic screen for dominant enhancers and suppressors of this phenotype identified mutations in a number of genes required for normal eye development, including UbcD1, which encodes a ubiquitin conjugating enzyme; SR3-4a, a gene previously implicated in signaling downstream of Ras1; and a Drosophila homolog of the Sin3A transcriptional repressor.

  • Received July 7, 1997.
  • Accepted September 23, 1997.
  • Copyright © 1998 by the Genetics Society of America
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Volume 148 Issue 1, January 1998

Genetics: 148 (1)

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A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

Thomas P. Neufeld, Amy H. Tang and Gerald M. Rubin
Genetics January 1, 1998 vol. 148 no. 1 277-286
Thomas P. Neufeld
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy H. Tang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerald M. Rubin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: gerry@fruitfly.berkeley.edu
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Citation

A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

Thomas P. Neufeld, Amy H. Tang and Gerald M. Rubin
Genetics January 1, 1998 vol. 148 no. 1 277-286
Thomas P. Neufeld
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy H. Tang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerald M. Rubin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: gerry@fruitfly.berkeley.edu

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  • Actin and Nuclear Envelope Components Influence Ectopic Recombination in the Absence of Swr1
  • Extending Tests of Hardy–Weinberg Equilibrium to Structured Populations
  • Selective Sweep at a QTL in a Randomly Fluctuating Environment
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