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Estimation of Deleterious-Mutation Parameters in Natural Populations

Hong-Wen Deng and Michael Lynch
Genetics September 1, 1996 vol. 144 no. 1 349-360
Hong-Wen Deng
Department of Biology, University of Oregon, Eugene, Oregon 97403
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  • For correspondence: deng@hgc.sph.uth.tmc.edu
Michael Lynch
Department of Biology, University of Oregon, Eugene, Oregon 97403
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Abstract

The rate and average effects of spontaneous deleterious mutations are important determinants of the evolution of breeding systems and of the vulnerability of small populations to extinction. Nevertheless, few attempts have been made to estimate the properties of such mutations, and those studies that have been performed have been extremely labor intensive, relying on long-term, laboratory mutation-accumulation experiments. We present an alternative to the latter approach. For populations in which the genetic variance for fitness is a consequence of selection-mutation balance, the mean fitness and genetic variance of fitness in outbred and inbred generations can be expressed as simple functions of the genomic mutation rate, average homozygous effect and average dominance coefficient of new mutations. Using empirical estimates for the mean and genetic variance of fitness, these expressions can then be solved to obtain joint estimates of the deleterious-mutation parameters. We employ computer simulations to evaluate the degree of bias of the estimators and present some general recommendations on the application of the technique. Our procedures provide some hope for obtaining estimates of the properties of deleterious mutations from a wide phylogenetic range of species as well as a mechanism for testing the validity of alternative models for the maintenance of genetic variance for fitness.

  • Received August 20, 1995.
  • Accepted April 24, 1996.
  • Copyright © 1996 by the Genetics Society of America
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Volume 144 Issue 1, September 1996

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Estimation of Deleterious-Mutation Parameters in Natural Populations

Hong-Wen Deng and Michael Lynch
Genetics September 1, 1996 vol. 144 no. 1 349-360
Hong-Wen Deng
Department of Biology, University of Oregon, Eugene, Oregon 97403
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: deng@hgc.sph.uth.tmc.edu
Michael Lynch
Department of Biology, University of Oregon, Eugene, Oregon 97403
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
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Citation

Estimation of Deleterious-Mutation Parameters in Natural Populations

Hong-Wen Deng and Michael Lynch
Genetics September 1, 1996 vol. 144 no. 1 349-360
Hong-Wen Deng
Department of Biology, University of Oregon, Eugene, Oregon 97403
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: deng@hgc.sph.uth.tmc.edu
Michael Lynch
Department of Biology, University of Oregon, Eugene, Oregon 97403
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

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