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Previous ArticleNext Article

Efficiency of marker-assisted selection in the improvement of quantitative traits.

R Lande and R Thompson
Genetics March 1, 1990 vol. 124 no. 3 743-756
R Lande
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
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R Thompson
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
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Abstract

Molecular genetics can be integrated with traditional methods of artificial selection on phenotypes by applying marker-assisted selection (MAS). We derive selection indices that maximize the rate of improvement in quantitative characters under different schemes of MAS combining information on molecular genetic polymorphisms (marker loci) with data on phenotypic variation among individuals (and their relatives). We also analyze statistical limitations on the efficiency of MAS, including the detectability of associations between marker loci and quantitative trait loci, and sampling errors in estimating the weighting coefficients in the selection index. The efficiency of artificial selection can be increased substantially using MAS following hybridization of selected lines. This requires initially scoring genotypes at a few hundred molecular marker loci, as well as phenotypic traits, on a few hundred to a few thousand individuals; the number of marker loci scored can be greatly reduced in later generations. The increase in selection efficiency from the use of marker loci, and the sample sizes necessary to achieve them, depend on the genetic parameters and the selection scheme.

  • Copyright © 1990 by the Genetics Society of America
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PUBLICATION INFORMATION

Volume 124 Issue 3, March 1990

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Research Support, U.S. Gov't, P.H.S.
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Efficiency of marker-assisted selection in the improvement of quantitative traits.

R Lande and R Thompson
Genetics March 1, 1990 vol. 124 no. 3 743-756
R Lande
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R Thompson
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
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Citation

Efficiency of marker-assisted selection in the improvement of quantitative traits.

R Lande and R Thompson
Genetics March 1, 1990 vol. 124 no. 3 743-756
R Lande
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R Thompson
Department of Ecology and Evolution, University of Chicago, Illinois 60637.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

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The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.

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