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Fine mapping of quantitative trait loci using selected overlapping recombinant chromosomes, in an interspecies cross of tomato.

A H Paterson, J W DeVerna, B Lanini and S D Tanksley
Genetics March 1, 1990 vol. 124 no. 3 735-742
A H Paterson
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
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J W DeVerna
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
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B Lanini
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
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S D Tanksley
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
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Abstract

Quantitative trait loci (QTLs) have been mapped to small intervals along the chromosomes of tomato (Lycopersicon esculentum), by a method we call substitution mapping. The size of the interval to which a QTL can be mapped is determined primarily by the number and spacing of previously mapped genetic markers in the region surrounding the QTL. We demonstrate the method using tomato genotypes carrying chromosomal segments from Lycopersicon chmielewskii, a wild relative of tomato with high soluble solids concentration but small fruit and low yield. Different L. chmielewskii chromosomal segments carrying a common restriction fragment length polymorphism were identified, and their regions of overlap determined using all available genetic markers. The effect of these chromosomal segments on soluble solids concentration, fruit mass, yield, and pH, was determined in the field. Many overlapping chromosomal segments had very different phenotypic effects, indicating QTLs affecting the phenotype(s) to lie in intervals of as little as 3 cM by which the segments differed. Some associations between different traits were attributed to close linkage between two or more QTLs, rather than pleiotropic effects of a single QTL: in such cases, recombination should separate desirable QTLs from genes with undesirable effects. The prominence of such trait associations in wide crosses appears partly due to infrequent reciprocal recombination between heterozygous chromosomal segments flanked by homozygous regions. Substitution mapping is particularly applicable to gene introgression from wild to domestic species, and generally useful in narrowing the gap between linkage mapping and physical mapping of QTLs.

  • Copyright © 1990 by the Genetics Society of America
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Volume 124 Issue 3, March 1990

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Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
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Fine mapping of quantitative trait loci using selected overlapping recombinant chromosomes, in an interspecies cross of tomato.

A H Paterson, J W DeVerna, B Lanini and S D Tanksley
Genetics March 1, 1990 vol. 124 no. 3 735-742
A H Paterson
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J W DeVerna
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B Lanini
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S D Tanksley
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
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Citation

Fine mapping of quantitative trait loci using selected overlapping recombinant chromosomes, in an interspecies cross of tomato.

A H Paterson, J W DeVerna, B Lanini and S D Tanksley
Genetics March 1, 1990 vol. 124 no. 3 735-742
A H Paterson
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J W DeVerna
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B Lanini
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S D Tanksley
Department of Plant Breeding and Biometry, Cornell University, Ithaca, New York 14853.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

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