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Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

E S Lander and D Botstein
Genetics January 1, 1989 vol. 121 no. 1 185-199
E S Lander
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
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D Botstein
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
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Abstract

The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms. We describe here a set of analytical methods that modify and extend the classical theory for mapping such quantitative trait loci (QTLs). These include: (i) a method of identifying promising crosses for QTL mapping by exploiting a classical formula of SEWALL WRIGHT; (ii) a method (interval mapping) for exploiting the full power of RFLP linkage maps by adapting the approach of LOD score analysis used in human genetics, to obtain accurate estimates of the genetic location and phenotypic effect of QTLs; and (iii) a method (selective genotyping) that allows a substantial reduction in the number of progeny that need to be scored with the DNA markers. In addition to the exposition of the methods, explicit graphs are provided that allow experimental geneticists to estimate, in any particular case, the number of progeny required to map QTLs underlying a quantitative trait.

  • Copyright © 1989 by the Genetics Society of America
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PUBLICATION INFORMATION

Volume 121 Issue 1, January 1989

ARTICLE CLASSIFICATION

INVESTIGATIONS
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
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Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

E S Lander and D Botstein
Genetics January 1, 1989 vol. 121 no. 1 185-199
E S Lander
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D Botstein
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
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Citation

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

E S Lander and D Botstein
Genetics January 1, 1989 vol. 121 no. 1 185-199
E S Lander
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D Botstein
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

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