98 Results
for term "sites"
- Effect of Misoriented Sites on Neutrality Tests With Outgroup...population of constant size. which is based on the total number of polymorphicDepartures from this model are typically attributed to sites, and Tajimas (1983) diversity (respectively) toselective or demographic effects. A rarely considered e, the number of derived unique mutations (mutationsalternative ~~~
- Activity-Dependent A-to-I RNA Editing in Rat Cortical Neurons...that short-term and persistent changes in neural activity can alter adenosine-to-inosine (A-to-I) RNA editing, a posttranscriptional site-specic modication found in several neuron-specic transcripts. In rat cortical neuron cultures, activity-dependent changes in A-to-I RNA editing in coding exons ~~~
- Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila...and TALEN) have been introduced into Drosophila to direct site-specic DNA double-strand breaks (DSBs) in the coding region of a target gene (Carroll 2011; Liu et al. 2012). During nonhomologous end joining (NHEJ) repair of the DSBs, mutations at the cut site lead to disruption of the target gene. For both ~~~
- Degradation of Centromeric Histone H3 Variant Cse4 Requires the Fpr3 Peptidyl-prolyl Cis–Trans Isomerase...that the Fpr3 proline isomerase activity is required for Cse4 protein stability (Figure 3, A and B). We next aimed to identify the target proline related to the Cse4 protein stability. There are ve proline sites in Cse4, which are P53, P98, P100, P134, and P157. We generated yeast strains bearing each ~~~
- Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation...damage checkpoint in syp-1 mutants (Figure 2C). During C. elegans development, egl-1 is transcriptionally regulated to limit somatic apoptosis to specic tissues in response to developmental cues (Nehme and Conradt 2008). Much of this regulation occurs at the egl-1 locus, where cisacting regulatory sites ~~~
- The Role of a Pollen-Expressed Cullin1 Protein in Gametophytic Self-Incompatibility in Solanum...site of S-locus ribonuclease is associated with self-compatibility in Lycopersicon peruvianum. Proc. Natl. Acad. Sci. USA 91: 65116514. Sijacic, P., W. Wang, A. L. Skirpan, Y. Wang, P. E. Dowd et al., 2004 Identication of the pollen determinant of S-RNase-mediated self-incompatibility. Nature 429 ~~~
- A Thermodynamic Switch for Chromosome Colocalization.... This colocalization mechanism is tunable by two thermodynamic switches, namely the concentration of molecular mediators and their affinity for their binding sites. When threshold values in the concentration, or affinity, of mediators are exceeded, homologous sequences are joined together; otherwise they move ~~~
- Identification of Small RNAs Associated with Meiotic Silencing by Unpaired DNA...is that these exonexon-specic RNAs could be secondary small RNAs resulting from the priming of siRNAs to mature mRNAs (which do not have introns). Reproducibility of site biases Small RNA-generating hot spots have been previously described in the biogenesis of siRNAs (Qi et al. 2009). We have observed reproducible ~~~
- On Relevance of Codon Usage to Expression of Synthetic and Natural Genes in Escherichia coli...to be established by further experimentation. A recent algorithm for estimating the efficiency of ribosomal binding sites from the mRNA sequence (Salis et al. 2009) explicitly takes into account the folding free energy of RNA secondary structures, along with other factors. When protein overexpression is desired ~~~
- Stress-Induced Mutation Rates Show a Sigmoidal and Saturable Increase Due to the RpoS Sigma Factor in Escherichia coli...genome per generation due to the lack of information on the number of sites in the cycA gene that can give rise to the CycR phenotype, which includes point mutations, small and large indels, and transpositions in cycA (Feher et al. 2006). Nevertheless, the CycR per-locus mutation rate in the strain ~~~