52 Results
for term "sites"
- ISSUE HIGHLIGHTS.... They carry out extensive simulations to test the statistical properties of this method, further validate it against experimental data, and apply it to five influenza virus data sets. The authors show that epistasis is widespread among these viruses and takes the form of networks of correlated sites ~~~
- ISSUE HIGHLIGHTS...to real data from HIV immunology and bacterial ecology. Remarkably long-tract gene conversion induced by fragile site instability in Saccharomyces cerevisiae, pp. 115128 Shahana A. Chumki, Mikael K. Dunn, Thomas F. Coates, Jeanmarie D. Mishler, Ellen M. Younkin, and Anne M. Casper Loss of heterozygosity ~~~
- ISSUE HIGHLIGHTS...sprouting, lose self-avoidance and auto-fuse to bypass the injury site. Branch pruning and arbor simplification completes regeneration. When auto-fusion fails the distal arbor degenerates. Coordination of double strand break repair and meiotic progression in yeast by a Mek1-Ndt80 negative feedback loop, pp ~~~
- ISSUE HIGHLIGHTS..., investigators could turn to MARRVEL when evaluating and prioritizing variants identified in the exomes of humans with rare disorders. By bringing together pertinent information form more than a dozen existing databases, MARRVEL might just become a site for one-stop shopping in the study and evaluation ~~~
- ISSUE HIGHLIGHTS...for inferring correlated fitness effects of same site nonsynonymous mutations, pp. 513523 Aaron P. Ragsdale, Alec J. Coffman, PingHsun Hsieh, Travis J. Struck, and Ryan N. Gutenkunst The proportion of mutations with different effects on fitness is a key parameter in evolutionary , but typical approaches ~~~
- ISSUE HIGHLIGHTS...of these introns have retained their ability to spread to intron-free target sites, often assisted by intron-encoded endonucleases that initiate the homing process. Repar and Warnecke show for different fungal species that genetic diversity in exons increases as one approaches a mobile intron. They rule out ~~~
- ISSUE HIGHLIGHTS...future efforts at identifying such loci. Preferential breakpoints in the recovery of broken dicentric chromosomes in Drosophila melanogaster, pp. 563572 Hunter Hill and Kent G.Golic Calvin Bridges first reported weak sites in polytene chromosomes of Drosophila melanogaster 80 years ago. In the late ~~~
- ISSUE HIGHLIGHTS...) between homologous chromosomes during meiosis: 1) recombinationindependent assessment of homology near special chromosome sites known as pairing centers, 2) a strong driving force favoring pairwise over multi-partner interactions, and 3) recombinationdependent maturation of homologous synapsis ~~~
- ISSUE HIGHLIGHTS...Principles of microRNA regulation revealed through modeling microRNA expression quantitative trait loci, pp. 16291640 Stefan Budach, Matthias Heinig, and Annalisa Marsico Transcriptional regulation of microRNAs is poorly understood, due to difficulties determining the start sites of transient ~~~
- ISSUE HIGHLIGHTS...Polyposis Coli (APC) is a negative regulator of Wnt signaling inactivated in over 80% of colorectal cancers. APC participates in the -catenin destruction complex; however, its mechanistic role remains unknown. Many models of APC function emphasize phosphorylation of its -catenin binding sites. To test ~~~

