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  • Molecular Population Genetics
    Sònia Casillas, Antonio Barbadilla
    Genetics March 2017 205: 1003-1035; https://doi.org/10.1534/genetics.116.196493
    ...relations and conveys no information about the underlying evolutionary forces. Also, they show that the discriminatory power of electrophoresis to detect protein variation is a decreasing function of the number of segregating sites. In summary, and given the limitations of protein electrophoresis to measure ~~~
  • Open Access
    Molecular Population Genetics
    Sònia Casillas, Antonio Barbadilla
    Genetics Mar 2017, 205 (3) 1003-1035; DOI: 10.1534/genetics.116.196493
    Figure 3
    Figure 3
    By Sònia Casillas and Antonio Barbadilla
    Molecular evolutionary rate (K) as a function of (A) the DFE, (B) the probability of fixation of new mutations entering the population, and (C) the rate at which new mutations enter the population per site per generation (see text for details). Different selection coefficients of mutations are colored in a gradient from maroon (strongly deleterious), red (slightly deleterious), gray (neutral), light green (slightly advantageous), and dark green (advantageous).
  • Open Access
    Molecular Population Genetics
    Sònia Casillas, Antonio Barbadilla
    Genetics Mar 2017, 205 (3) 1003-1035; DOI: 10.1534/genetics.116.196493
    Figure 5
    Figure 5
    By Sònia Casillas and Antonio Barbadilla
    Representation of the cost of linkage on selected sites, or HRi. Arrows indicate adaptive (green) and deleterious (red) mutations, while their length indicates the intensity of selection. (A) When two or more adaptive mutations occur in separate haplotypes without recombination (left), only one of them can be fixed in the population and thus mutations compete for their fixation. However, when recombination is sufficiently high (right), the two haplotypes can exchange alleles and generate a new haplotype that carries both adaptive mutations and can be fixed. (B) In the presence of both adaptive and deleterious mutations without recombination (left), all alleles compete; as a result, deleterious alleles may be dragged to fixation if the intensity of selection favoring a nearby adaptive mutation is high, or adaptive alleles may be lost if the joint strength of negative selection is higher. With recombination (right), deleterious alleles can be removed and adaptive alleles can be fixed without interfering with each other. Adapted from Barrón (2015).
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