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  • Genome-Wide Characterization of Tetrahymena thermophila Chromosome Breakage Sites. I. Cloning and Identification of Functional Sites
    Eileen Hamilton, Peter Bruns, Cindy Lin, Virginia Merriam, Eduardo Orias, Linh Vong, Donna Cassidy-Hanley
    Genetics August 2005 170: 1611-1621; https://doi.org/10.1534/genetics.104.031401
    ...for publication May 10, 2005 ABSTRACT The chromosomes of the macronuclear (expressed) genome of Tetrahymena thermophila are generated by developmental fragmentation of the five micronuclear (germline) chromosomes. This fragmentation is site specific and directed by a conserved 15-bp chromosome breakage sequence ~~~
  • Genome-Wide Characterization of Tetrahymena thermophila Chromosome Breakage Sites. II. Physical and Genetic Mapping
    Donna Cassidy-Hanley, Yelena Bisharyan, Vladimir Fridman, Joseph Gerber, Cindy Lin, Eduardo Orias, Judith D. Orias, Hilary Ryder, Linh Vong, Eileen P. Hamilton
    Genetics August 2005 170: 1623-1631; https://doi.org/10.1534/genetics.104.031435
    ...) genome of Tetrahymena thermophila are generated by developmental fragmentation of the five micronuclear (germline) chromosomes. This fragmentation is site specific, directed by a conserved chromosome breakage sequence (Cbs element). An accompanying article in this issue reports the development ~~~
  • Effects of Natural Selection on Interpopulation Divergence at Polymorphic Sites in Human Protein-Coding Loci
    Austin L. Hughes, Bernice Packer, Robert Welch, Andrew W. Bergen, Stephen J. Chanock, Meredith Yeager
    Genetics July 2005 170: 1181-1187; https://doi.org/10.1534/genetics.104.037077
    ...was evidence of purifying selection acting at these sites, which in turn causes a reduction in interpopulation divergence. By contrast, a small number of SNP sites in these categories revealed unusually high genetic distances between the two most diverged populations (African and Asian); these loci may have ~~~
  • Codon-Substitution Models for Heterogeneous Selection Pressure at Amino Acid Sites
    Ziheng Yang, Rasmus Nielsen, Nick Goldman, Anne-Mette Krabbe Pedersen
    Genetics May 2000 155: 431-449;
    ...5 1 meaning neutral mutations, v , 1 purifying selection, and v . 1 diversifying positive selection. Amino acid sites in a protein are expected to be under different selective pressures and have different underlying v ratios. We develop models that account for heterogeneous v ratios among amino acid ~~~
  • The Expected Number of Heterozygous Sites in a Subdivided Population
    Thomas Nagylaki
    Genetics July 1998 149: 1599-1604;
    ...of heterozygous sites per individual at equilibrium in a subdivided population. The model of innitely many neutral sites is posited; the linkage map is arbitrary. The monoecious, diploid population is subdivided into a nite number of panmictic colonies that exchange gametes. The backward migration matrix ~~~
  • A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
    Mary Ellen Lane, Marion Elend, Doris Heidmann, Anabel Herr, Sandra Marzodko, Alf Herzig, Christian F. Lehner
    Genetics May 2000 155: 233-244;
    ...Copyright 2000 by the Genetics Society of America A Screen for Modiers of Cyclin E Function in Drosophila melanogaster Identies Cdk2 Mutations, Revealing the Insignicance of Putative Phosphorylation Sites in Cdk2 Mary Ellen Lane,1 Marion Elend,2 Doris Heidmann, Anabel Herr, Sandra Marzodko ~~~
  • The Allele-Specific Suppressor sup-39 Alters Use of Cryptic Splice Sites in Caenorhabditis elegans
    A. Brock Roller, David C. Hoffman, Alan M. Zahler
    Genetics March 2000 154: 1169-1179;
    ...Copyright 2000 by the Genetics Society of America The Allele-Specic Suppressor sup-39 Alters Use of Cryptic Splice Sites in Caenorhabditis elegans A. Brock Roller, David C. Hoffman and Alan M. Zahler Department of Biology and Center for Molecular Biology of RNA, University of California, Santa ~~~
  • Correlation Between the Substitution Rate and Rate Variation Among Sites in Protein Evolution
    Jianzhi Zhang, Xun Gu
    Genetics July 1998 149: 1615-1625;
    ...ABSTRACT It is well known that the rate of amino acid substitution varies among different proteins and among different sites of a protein. It is, however, unclear whether the extent of rate variation among sites of a protein and the mean substitution rate of the protein are correlated. We used two ~~~
  • Preferential transposition of Drosophila P elements to nearby chromosomal sites.
    J Tower, G H Karpen, N Craig, A C Spradling
    Genetics February 1993 133: 347-359;
    ...Copyright 0 1993 by the Genetics Society of America Preferential Transposition of Drosophila P Elements to Nearby Chromosomal Sites John Tower, Gary H. Karpen,* Nancy Craig3 and Allan C. Spradling Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore ~~~
  • Two Sites in the Delta Gene Region Contribute to Naturally Occurring Variation in Bristle Number in Drosophila melanogaster
    Anthony D. Long, Richard F. Lyman, Charles H. Langley, Trudy F. C. Mackay
    Genetics June 1998 149: 999-1017;
    ...the signicance of the molecular marker with the largest effect on bristle variation in four genetic backgrounds relative to permuted data-sets, found two sites that were independently associated with variation in bristle number. A common site in the second intron of Delta affected only sternopleural ~~~

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