18,406 Results
for term "sites"
- Selection on Inversion Breakpoints Favors Proximity to Pairing Sensitive Sites in Drosophila melanogaster...the distribution of inversion breakpoints remain poorly understood. Sensitive sites have been mapped on all euchromatic chromosome arms in Drosophila melanogaster, and may be a source of natural selection on inversion breakpoint positions. Briey, sensitive sites are genomic regions wherein proximal structural ~~~
- DNA Replication Stress Phosphoproteome Profiles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiae...| INVESTIGATION DNA Replication Stress Phosphoproteome Proles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiae Dongqing Huang, Brian D. Piening,1 Jacob J. Kennedy, Chenwei Lin, Corey W. Jones-Weinert, Ping Yan, and Amanda G. Paulovich2 Fred Hutchinson Cancer ~~~
- Selection Against Maternal microRNA Target Sites in Maternal Transcripts...suggest that maternal transcripts tend to avoid target sites for maternal microRNAs. I also developed a microRNA target mutation model to study the functional impact of polymorphisms at microRNA target sites. The analysis of Drosophila populations suggests that there is selection against maternal micro ~~~
- Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites...2005), which in Escherichia coli are encoded by seven virtually identical rrn operons: rrnA through rrnH (rrnFwas renamed as rrnG) (supporting information, Figure S1A). This sevenfold redundancy limits the introduction of resistance caused by binding site mutations, mainly due to the recessive nature ~~~
- Generating Customized Transgene Landing Sites and Multi-Transgene Arrays in Drosophila Using phiC31 Integrase...GENETICS | INVESTIGATION Jon-Michael Knapp,1 Phuong Chung, and Julie H. Simpson1 Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 ABSTRACT Transgenesis in numerous eukaryotes has been facilitated by the use of site-specic integrases to stably insert transgenes ~~~
- Enrichment of H3K9me2 on Unsynapsed Chromatin in Caenorhabditis elegans Does Not Target de Novo Sites...to disable X chromosome synapsis and performed a combination of molecular assays to map the sites of H3K9me2 accumulation, evaluate H3K9me2 abundance in germline vs. whole animals, and evaluate the impact of H3K9me2 loss on the germline transcriptome. Our data indicate that H3K9me2 is elevated broadly across ~~~
- Multiple Conserved Heteroplasmic Sites in tRNA Genes in the Mitochondrial Genomes of Terrestrial Isopods (Oniscidea)...dimers. This unusual organization is associated with an ancient and conserved constitutive heteroplasmic site. This heteroplasmy affects the anticodon of a tRNA gene, allowing this single locus to function as a dual tRNA gene for two different amino acids. Here, we further explore the evolution ~~~
- Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans...to antigenic peptides and GFP. Whole-genome sequencing of ve edited strains revealed the presence of passenger variants, but no mutations at predicted off-target sites. The method is scalable for multi-gene editing projects and could be applied to other animals with an accessible germline. THE ultimate goal ~~~
- Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies...INVESTIGATION Katherine Chuang, Eileen Nguyen, Yuri Sergeev, and Tudor C. Badea1 Retinal Circuits Development and Genetics Unit, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 ABSTRACT Site-specic recombinases (SSRs) such as Cre are widely used in gene targeting ~~~
- Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites.... Supporting information is available online at www..org/lookup/suppl/ doi:10.1534/.115.177816/-/DC1. 1Corresponding author: North Carolina State University, 2601 Stinson Dr., Raleigh, NC 27607. E-mail: eric_stone@ncsu.edu Genetics, Vol. 202, 427437 February 2016 427 number of polymorphic sites, exploration ~~~