26 Results
for term "sites"
- A Phylogenetic Codon Substitution Model for Antibody Lineages...substitution model that partially accounts for this context dependency while preserving independence of sites during calculation. This model shows a substantially better t to three well-characterized bNAb lineages than the standard GY94 model. We also demonstrate how our model can be used to test hypotheses ~~~
- The Immune Phenotype of Three Drosophila Leukemia Models...or combined with knockdowns of tumor suppressors in Drosophila hemocytes. Our results show that phagocytosis, hemocyte migration to wound sites, wound sealing, and survival upon bacterial infection of leukemic lines are similar to wild type. We nd that in all leukemic models the two major immune pathways ~~~
- Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host...factors binding sites in the promoter regions of infection-regulated genes. In addition, we show that MDL-1::GFP and MML-1::GFP proteins are expressed in intestinal nuclei during infection, and we characterize other transcription factors that regulate pathogen development for their interaction with MDL-1 ~~~
- Genome-Wide Exome Analysis of Cmv5-Disparate Mouse Strains that Differ in Host Resistance to Murine Cytomegalovirus Infection...based on analysis of extant mouse strains using classical genetics (Poltorak et al. 1998; Brown et al. 2001; Xie et al. 2010), site-directedmutagenesis of the well-known B6 mouse strain (Nelms and Goodnow 2001; Hoebe et al. 2003), and the more recent collaborative cross of eight different laboratory ~~~
- Population Genetics of Anopheles coluzzii Immune Pathways and Genes...amino acid differences near the predicted peptide cleavage site, are also segregating in the sister species A. gambiae (S form) and A. arabiensis. Comparison of the two haplotypes between species indicates that they were not shared among the species through introgression, but rather that they arose ~~~
- Nonsynonymous Substitution Rate Heterogeneity in the Peptide-Binding Region Among Different HLA-DRB1 Lineages in Humans...were responsible for the stagnation of accumulation of PBR nonsynonymous substitutions. From these observations, we conclude that the nonsynonymous substitution rate at the PBR sites is not constant among the allelic lineages. The deceleration of the rate may be caused by the coexistence of certain ~~~
- The Roles of Two miRNAs in Regulating the Immune Response of Sea Cucumber...(http://www.smart.emblheidelbergde/). 39-UTR luciferase reporter assay The 39-UTR of AjBHMTmRNA, containing the putative target site of miR-137 and miR-2008, was cloned into the pMIRREPORT luciferase plasmid (Promega) between theMluI and HindIII restriction sites and subsequently subjected to DNA Figure ~~~
- Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus...association evidence in the Han Chinese population to an enrichment test of expression quantitative trait locus (QTL) sites and DNase I hypersensitivity, respectively. In both Eastern Asian and Caucasian populations, we observed that the expression level of SLE GWAS implicated genes was signicantly elevated ~~~
- Effector-Triggered Immune Response in Arabidopsis thaliana Is a Quantitative Trait...cascade called microbe (pathogen)-triggered immunity (MTI). MTI leads to production of reactive oxygen, secretion of pathotoxins, and reinforcement of cell walls at the infection site, which collectively protect the plant from infection. Successful pathogens introduce into host cells effector proteins ~~~
- Genomic Signatures of Experimental Adaptation to Antimicrobial Peptides in Staphylococcus aureus...for the three phage excision sites in the 8325 reference genome. JLA513 reads were then mapped to the resulting sequence and bcftools consensus (H. Li et al. 2009) was used to correct the remaining 13 SNPs and two indels. To identify mutations in the selection lines, reads were mapped to this reference genome ~~~