154 Results
for term "sites"
- Emergence of a Novel Chimeric Gene Underlying Grain Number in Rice...of LOC_Os02g56630, 22 pairs of specic primers covering a 3-kb genomic region surrounding the insertion site were designed to analyze the complementary DNA (cDNA) of YIL19 and Teqing. The RT-PCR products were conrmed by gel electrophoresis and sequence analyses. Real-time quantitative PCR (RT ~~~
- The Genomic Architecture of Interactions Between Natural Genetic Polymorphisms and Environments in Yeast Growth...of antagonism in the other environment increases. Antagonistic g3eQTLs are enriched in dissimilar environments. Relative to gQTLs, g3eQTLs tend to occur at intronic and synonymous sites. The gene ontology (GO) distributions of gQTLs and g3eQTLs are signicantly different, as are those of antagonistic ~~~
- Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration...site appear undisputed, the ARMS2/HTRA1 region proved notoriously difcult to dissect by statistical means as the chromosomal region displays correlated variants in high linkage disequilibrium (LD) (Dewan et al. 2006; Fritsche et al. 2008; Kanda et al. 2010; Yang et al. 2010; Friedrich et al. 2011 ~~~
- Trends in DNA Methylation with Age Replicate Across Diverse Human Populations...with widespread changes in genome-wide patterns of DNA methylation. Thousands of CpG sites whose tissue-specic methylation levels are strongly correlated with chronological age have been previously identied. However, the majority of these studies have focused primarily on cosmopolitan populations living ~~~
- Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA2 Locus..., we began by performing a detailed screen for mutations of potential functional signicance (nonsynonymous, stop/gain, frameshifts, and splice site mutations). We compared the pool containing dw/dw individuals, which are supposed to be homozygous for the causative mutation, to previously reported ~~~
- The Genomic Architecture of Flowering Time Varies Across Space and Time in Mimulus guttatus...EwiE xiLwiL wiE wiL : (2) Here, xiE and xiL are the estimates from each bulk at site i and w terms are the reciprocal of s2iB 1=miB viB; where B designates early or late bulk. The log-likelihood of the data under the model (after dropping a common term across models) is: LLi xiE2x ~~~
- Genetic Architectures of Quantitative Variation in RNA Editing Pathways...the specicity and degree of editing are not well understood. We examined quantitative variation of site-specic editing in a genetically diverse multiparent population, Diversity Outbred mice, and mapped polymorphic loci that alter editing ratios globally for C-to-U editing and at specic sites for A ~~~
- Imputation of DNA Methylation Levels in the Brain Implicates a Risk Factor for Parkinson’s Disease.... Imputation of such intermediate phenotypes represents a practical alternative in this context. We used a mixed linear model to impute DNAmethylation (DNAm) levels of four brain tissues at up to 1826 methylome-wide sites in 6259 patients with Parkinsons disease and 9452 controls from across ve genome ~~~
- Genome-Wide Variation of Cytosine Modifications Between European and African Populations and the Implications for Complex Traits...G sites showed differential modication between the two populations at a false discovery rate of 1%. The CpG sites with greater modication levels in European descent were enriched in the proximal regulatory regions, while those greater in African descent were biased toward gene bodies. More than half ~~~
- Evidence That the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1...luciferase reporter assays were used to determine the repressor function of tga1 in transient protoplast expression experiments. N-terminal sequences of tga1 were fused to a GAL4-DNA binding domain (DBD) and cotransformed with a rey luciferase gene downstream of two GAL4 binding sites. Firey luciferase ~~~