607 Results
for term "sites"
- Correlated Mutations and Homologous Recombination Within Bacterial Populations...model circular genomes of length L with an alphabet of size a letters, where the usual choice is a 4; corresponding to the four bases of DNA. Each site on a genome mutates with rate m (per generation) to any of the a2 1 remaining letters with equal probability. DNA transfer events, in which ~~~
- The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit...errors. In addition, we removed sites with sequencing depth lower than 10 for all individuals or higher than 500 that likely belong to repetitive regions. The resulting dataset comprise 133,808 SNVs within the exome. This dataset was used solely for identifying absolute numbers of SNVs across a number ~~~
- Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development...2010; Spitz and Furlong 2012; Yanez-Cuna et al. 2012; Slattery et al. 2013, 2014). These changes in binding site occupancy by sequence-specic transcription factors are regulated largely through alterations in chromatin structure that modulate the accessible regions of the genome (Kaplan et al. 2011 ~~~
- Highly Efficient Cpf1-Mediated Gene Targeting in Mice Following High Concentration Pronuclear Injection...guides with close targeting sites can result in synergistic genomic cutting, even if one of the guides has minimal cutting activity. KEYWORDS Cpf1 nuclease genome editing CRISPR mouse The CRISPR/Cas9 systems have revolutionized genome editing in many model and nonmodel organisms. Because of its high ~~~
- Selection Limits to Adaptive Walks on Correlated Landscapes...in the weak-mutation regime and characterize the conditions that enable them to quickly reach the tness peak as a function of the number of sites under selection. We show that for additive landscapes there is a critical selection strength enabling populations to reach high-tness genotypes, regardless ~~~
- Inferring Ancestral Recombination Graphs from Bacterial Genomic Data...under a model of molecular evolution, which, in combination with a standard substitution model, includes effects similar to those resulting from gene conversion; instantaneous events that simultaneously produce character-state changes at multiple sites within a randomly positioned conversion tract ~~~
- Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.... Moreover, the ability of the su(Hw) insulator to prevent crosstalk between iab-6 and iab-7 is tissue specic, and is lost in the embryonic CNS. The Fab-7 insulator has also been replaced with multimerized dCTCF sites and boundaries from BX-C (Kyrchanova et al. 2016). Surprisingly, only Fab-8 was able ~~~
- Feeding-Related Traits Are Affected by Dosage of the foraging Gene in Drosophila melanogaster...-dependent relationship between the foraging gene and its pleiotropic inuence on these feeding-related traits. Our analysis of foragings transcription start sites, termination sites, and splicing patterns using rapid amplication of cDNA ends (RACE) and full-length cDNA sequencing, revealed four independent promoters ~~~
- Genomic Prediction with Pedigree and Genotype × Environment Interaction in Spring Wheat Grown in South and West Asia, North Africa, and Mexico..., and different management factors. Burgueo et al. (2012) were the rst to use marker- and pedigree-based Best Linear Unbiased Predictor (BLUP) models for assessing GE under genomic prediction; these models account for correlated environmental Figure 1 Geographical distribution of the sites where the wheat ~~~
- The Role of +4U as an Extended Translation Termination Signal in Bacteria...-cognate tRNAs that decode codons differing from UAA by a single nucleotide), particularly those with a mismatch at the rst stop codon site. UAA is always the preferred stop codon in HEGs, and our results suggest that UAAU is the most efcient translation termination signal in bacteria. KEYWORDS translation ~~~