2,824 Results
for term "sites"
- Why Transcription Factor Binding Sites Are Ten Nucleotides Long...Park, MD 20742 ABSTRACT Gene expression is controlled primarily by transcription factors, whose DNA binding sites are typically 10 nt long. We develop a population-genetic model to understand how the length and information content of such binding sites evolve. Our analysis is based on an inherent trade ~~~
- The Effects of Deleterious Mutations on Evolution at Linked Sites...REVIEW Brian Charlesworth1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom ABSTRACT The process of evolution at a given site in the genome can be inuenced by the action of selection at other sites, especially when ~~~
- Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila...of MIC-specic DNA removal that pinpoints MAC genome sites of DNA elimination at nucleotide resolution. The widespread distribution of internal eliminated sequences (IES) in promoter regions and introns suggests that MAC genome restructuring is essential not only for what it removes (for example, active ~~~
- Human Triallelic Sites: Evidence for a New Mutational Mechanism?...23, 2009 ABSTRACT Most SNPs in the human genome are biallelic; however, there are some sites that are triallelic. We show here that there are approximately twice as many triallelic sites as we would expect by chance. This excess does not appear to be caused by natural selection or mutational hotspots ~~~
- Sites of Recombination Are Local Determinants of Meiotic Homolog Pairing in Saccharomyces cerevisiae...received June 15, 2007 Accepted for publication April 4, 2008 ABSTRACT Trans-acting factors involved in the early meiotic recombination pathway play a major role in promoting homolog pairing during meiosis in many plants, fungi, and mammals. Here we address whether or not allelic sites have higher levels ~~~
- Inference of Population Mutation Rate and Detection of Segregating Sites from Next-Generation Sequence Data...for detection of polymorphic sites for NGS data. Li and Leal (2009) developed a Bayesian method for computing individual genotype likelihood values from NGS data. There are also approaches that combine the resequenced data of the samples for better SNP calling. For example, Bansal et al. (2010) used a method ~~~
- Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans...INVESTIGATION Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantication of Selection on Nonsynonymous and Synonymous Sites in Humans Peter D. Keightley1 and Daniel L. Halligan Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh ~~~
- Extensive Loss of RNA Editing Sites in Rapidly Evolving Silene Mitochondrial Genomes: Selection vs. Retroprocessing as the Driving Force...University, Bloomington, Indiana 47405 Manuscript received April 20, 2010 Accepted for publication May 7, 2010 ABSTRACT Theoretical arguments suggest that mutation rates influence the proliferation and maintenance of RNA editing. We identified RNA editing sites in five species within the angiosperm genus ~~~
- The Polymorphism Frequency Spectrum of Finitely Many Sites Under Selection...uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that is reasonable for most eukaryotic populations, but that becomes problematic when u is large (u* 0.05). Here, we show that at large ~~~
- Second-Order Moments of Segregating Sites Under Variable Population Size...-occurrence of population size changes and selection. To delimit this problem and gain better insights into demographic factors, theoretical results regarding the second-order moments of segregating sites, such as the variance of segregating sites, have been derived. Driven by emerging genomewide surveys, which allow ~~~