18,409 Results
for term "sites"
- Genetic Variant Selection: Learning Across Traits and Sites...prior distributions that facilitate learning the role of each variable site by borrowing evidence across phenotypes and across mutations in the same gene. We illustrate their potential advantages with simulations and reanalyzing a data set of sequencing variants. KEYWORDS Bayesian variant selection; ne ~~~
- Chromatin Organization and Remodeling of Interstitial Telomeric Sites During Meiosis in the Mongolian Gerbil (Meriones unguiculatus)...sites (ITSs) can also be found along the chromosomes, especially near the centromere, where they may appear following chromosomal rearrangements like Robertsonian translocations. There is no dened role for ITSs, but they are linked to DNA damage-prone sites. We were interested in studying ~~~
- CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells...(Dock7), for which we were unsuccessful in generating a allele using a KOMP targeted ES cell clone. The strategy was to insert loxP sites to ank either exons 3 and 4, or exons 3 through 7. By coinjecting Cas9 mRNA, validated sgRNAs, and oligonucleotide donors into fertilized eggs from C57BL/6J ~~~
- Binding Sites in the EFG1 Promoter for Transcription Factors in a Proposed Regulatory Network: A Functional Analysis in the White and Opaque Phases of Candida albicans...in the white phase of the white-opaque transition, is essential for expression of the white phenotype. It is one of six transcription factors included in a proposed interactive transcription network regulating white-opaque switching and maintenance of the alternative phenotypes. Ten sites were identied ~~~
- Large-Scale Mapping of Transposable Element Insertion Sites Using Digital Encoding of Sample Identity.... 2009; Goodman et al. 2009; Prabhu and Peer 2009). Transposable elements represent powerful tools for manipulating the genomes of many model organisms (Bellen et al. 2011; Bire and Rouleux-Bonnin 2012). Thus, determining the genomic location of transposon insertion sites is a common experimental goal ~~~
- Why Transcription Factor Binding Sites Are Ten Nucleotides Long...Park, MD 20742 ABSTRACT Gene expression is controlled primarily by transcription factors, whose DNA binding sites are typically 10 nt long. We develop a population-genetic model to understand how the length and information content of such binding sites evolve. Our analysis is based on an inherent trade ~~~
- Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation...bias. Intriguingly, we observed an increased mutation rate at cytosine nucleotides, specically CpG nucleotides, which is also seen in S. cerevisiae. However, the absence of methylation in Sc. pombe and the pattern of mutation at these sites, primarily C/ A as opposed to C/ T, strongly suggest ~~~
- The Effects of Deleterious Mutations on Evolution at Linked Sites...REVIEW Brian Charlesworth1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom ABSTRACT The process of evolution at a given site in the genome can be inuenced by the action of selection at other sites, especially when ~~~
- Variation in Meiotic Recombination Frequencies Between Allelic Transgenes Inserted at Different Sites in the Drosophila melanogaster Genome...of females. We found that the recombination frequency at a site in the middle of the X chromosome, where crossovers are normally frequent, was similar to the frequency at the centromereproximal end of the euchromatin, where crossovers are normally infrequent. In contrast, we recovered no recombinants ~~~
- Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila...of MIC-specic DNA removal that pinpoints MAC genome sites of DNA elimination at nucleotide resolution. The widespread distribution of internal eliminated sequences (IES) in promoter regions and introns suggests that MAC genome restructuring is essential not only for what it removes (for example, active ~~~