7,118 Results

• Estimation of the Amount of DNA Polymorphism When the Neutral Mutation Rate Varies Among Sites

  Kazuharu Misawa, Fumio Tajima

  Genetics December 1997 147: 1959-1964;

  ...of DNA polymorphism is essential to understand the mechanism of maintaining DNA polymorphism in a natural population. The amount of DNA polymorphism can be measured by the average number of nucleotide differences per site (T), the proportion of segregating (polymorphic) site (s) and the minimum number ~~~
• Codon-Substitution Models for Heterogeneous Selection Pressure at Amino Acid Sites

  Ziheng Yang, Rasmus Nielsen, Nick Goldman, Anne-Mette Krabbe Pedersen

  Genetics May 2000 155: 431-449;

  ...5 1 meaning neutral mutations, v , 1 purifying selection, and v . 1 diversifying positive selection. Amino acid sites in a protein are expected to be under different selective pressures and have different underlying v ratios. We develop models that account for heterogeneous v ratios among amino acid ~~~
• The Expected Number of Heterozygous Sites in a Subdivided Population

  Thomas Nagylaki

  Genetics July 1998 149: 1599-1604;

  ...of heterozygous sites per individual at equilibrium in a subdivided population. The model of innitely many neutral sites is posited; the linkage map is arbitrary. The monoecious, diploid population is subdivided into a nite number of panmictic colonies that exchange gametes. The backward migration matrix ~~~
• A Test of Whether Selection Maintains Isochores Using Sites Polymorphic for Alu and L1 Element Insertions

  Elise M. S. Belle, Adam Eyre-Walker

  Genetics February 2002 160: 815-817;

  ...October 22, 2001 ONE of the most striking features of the human Although we have little direct information about thepattern of element integration, we can use sites that aregenome is the large-scale variation in GC content that is found along chromosomes. This variation was polymorphic for SINE and LINE ~~~
• Analysis of Recombination Sites Within the Maize waxy Locus

  Ron J. Okagaki, Clifford F. Weil

  Genetics October 1997 147: 815-821;

  ...Copyright 0 1997 by the Genetics Society of America Analysis of Recombination Sites Within the Maize waxy Locus Ron J. Okagaki and Clifford F. Weilt *Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 and +Department of Biological Sciences, University of Idaho, Moscow, Idaho ~~~
• A Novel Method for Estimating Substitution Rate Variation Among Sites in a Large Dataset of Homologous DNA Sequences

  Graziano Pesole, Cecilia Saccone

  Genetics February 2001 157: 859-865;

  ...July 18, 2000 Accepted for publication October 10, 2000 ABSTRACT We present here a novel method to estimate the site-specific relative variability in large sets of homologous sequences. It is based on the simple idea that the more closely related are the compared sequences, the higher the probability ~~~
• A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2

  Mary Ellen Lane, Marion Elend, Doris Heidmann, Anabel Herr, Sandra Marzodko, Alf Herzig, Christian F. Lehner

  Genetics May 2000 155: 233-244;

  ...Copyright 2000 by the Genetics Society of America A Screen for Modiers of Cyclin E Function in Drosophila melanogaster Identies Cdk2 Mutations, Revealing the Insignicance of Putative Phosphorylation Sites in Cdk2 Mary Ellen Lane,1 Marion Elend,2 Doris Heidmann, Anabel Herr, Sandra Marzodko ~~~
• The Allele-Specific Suppressor sup-39 Alters Use of Cryptic Splice Sites in Caenorhabditis elegans

  A. Brock Roller, David C. Hoffman, Alan M. Zahler

  Genetics March 2000 154: 1169-1179;

  ...Copyright 2000 by the Genetics Society of America The Allele-Specic Suppressor sup-39 Alters Use of Cryptic Splice Sites in Caenorhabditis elegans A. Brock Roller, David C. Hoffman and Alan M. Zahler Department of Biology and Center for Molecular Biology of RNA, University of California, Santa ~~~
• Natural Selection on Synonymous Sites Is Correlated With Gene Length and Recombination in Drosophila

  Josep M. Comeron, Martin Kreitman, Montserrat Aguadé

  Genetics January 1999 151: 239-249;

  ...selection on synonymous sites is strongly correlated with the rate of recombination, in accord with the nearly neutral hypothesis. This correlation, however, is apparent only in genes encoding short proteins. Long coding regions have both a lower codon bias and higher synonymous substitution rates ~~~
• Correlation Between the Substitution Rate and Rate Variation Among Sites in Protein Evolution

  Jianzhi Zhang, Xun Gu

  Genetics July 1998 149: 1615-1625;

  ...ABSTRACT It is well known that the rate of amino acid substitution varies among different proteins and among different sites of a protein. It is, however, unclear whether the extent of rate variation among sites of a protein and the mean substitution rate of the protein are correlated. We used two ~~~

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