70 Results
for term "sites"
- The Effects of Deleterious Mutations on Evolution at Linked Sites...REVIEW Brian Charlesworth1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom ABSTRACT The process of evolution at a given site in the genome can be inuenced by the action of selection at other sites, especially when ~~~
- An Evolutionary Perspective on Yeast Mating-Type Switching...binding sites upstream of asgs to Figure 2 Gene organization in the MAT, HML, and HMR loci on S. cerevisiae chromosome III. Shading indicates genes whose transcription is repressed. Review 11 repress them in a haploids (Tsong et al. 2006), the gain of Ste12 binding sites upstream of asgs so ~~~
- A Mouse Geneticist’s Practical Guide to CRISPR Applications...uses a homologous template, usually a sister chromatid under natural circumstances, to repair DNA damage if DNA replication has already occurred. Therefore, codelivering the site-specic nuclease with an alternative repair template, such as a plasmid or single-stranded oligodeoxynucleotide (ss ~~~
- Challenges in Species Tree Estimation Under the Multispecies Coalescent Model...by themutational distance, so that one time unit is dened as the amount of time taken to accumulate onemutation per site in the sequence. Then coalescent between two sequences occurs at the rate of 2u per time unit, and the average coalescent waiting time is u=2; where u = 4Nm is the expected number of mutations ~~~
- Reexamining the P-Element Invasion of Drosophila melanogaster Through the Lens of piRNA Silencing...), causing P transposase to inhibit the binding of transcription factor IID and subsequent RNA polymerase recruitment (Figure 1B) (Kaufman and Rio 1991). The site-specic binding domain of P transposase is found in both type I and type II repressors (Figure 1), and type II repressors are empirically known ~~~
- Tools for Predicting the Functional Impact of Nonsynonymous Genetic Variation...of a protein. However, only a subset of NSVs have a damaging functional effect (i.e., affecting the biochemical activity or regulatory control of a protein), as proteins are large molecules and their structures can be quite robust to single-site mutations. Note that the term damaging does not necessarily ~~~
- Rates and Fitness Consequences of New Mutations in Humans...REVIEW Peter D. Keightley1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom ABSTRACT The human mutation rate per nucleotide site per generation (m) can be estimated from data on mutation rates at loci causing Mendelian ~~~
- Programmed Cell Death Initiation and Execution in Budding Yeast...but differ with respect to substrate recognition sites (asparagine/lysine rather than aspartic acid). Budding yeast possesses a single metacaspase (Yca1) and BH3 domain protein (Ybh3), which are both required for oxidative stress-induced PCD. Standard assays for PCD, such as double strand breaks ~~~
- The Molecular Genetics of Insecticide Resistance...of the mutations involved. Molecular analysis has conrmed the relative importance of single major genes in target-site resistance and has also revealed some interesting surprises about the multi-gene families, such as cytochrome P450s, involved in metabolic resistance. Identication of the mutations involved ~~~
- The Evolutionary Origin and Genetic Makeup of Domestic Horses...betweenwild and early domestic individuals, but also due to the scarcity of paleontological records from some key periods, especially the one preceding the earliest evidence of domestication. This evidence is given by the#1;5500-year-old archaeological site of Botai (modern-day Kazakhstan) (Outram et al. 2009 ~~~