667 Results
for term "sites"
- Selection on Inversion Breakpoints Favors Proximity to Pairing Sensitive Sites in Drosophila melanogaster...the distribution of inversion breakpoints remain poorly understood. Sensitive sites have been mapped on all euchromatic chromosome arms in Drosophila melanogaster, and may be a source of natural selection on inversion breakpoint positions. Briey, sensitive sites are genomic regions wherein proximal structural ~~~
- Why Transcription Factor Binding Sites Are Ten Nucleotides Long...Park, MD 20742 ABSTRACT Gene expression is controlled primarily by transcription factors, whose DNA binding sites are typically 10 nt long. We develop a population-genetic model to understand how the length and information content of such binding sites evolve. Our analysis is based on an inherent trade ~~~
- Inference of Population Mutation Rate and Detection of Segregating Sites from Next-Generation Sequence Data...for detection of polymorphic sites for NGS data. Li and Leal (2009) developed a Bayesian method for computing individual genotype likelihood values from NGS data. There are also approaches that combine the resequenced data of the samples for better SNP calling. For example, Bansal et al. (2010) used a method ~~~
- Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans...INVESTIGATION Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantication of Selection on Nonsynonymous and Synonymous Sites in Humans Peter D. Keightley1 and Daniel L. Halligan Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh ~~~
- Correlated Mutations and Homologous Recombination Within Bacterial Populations...model circular genomes of length L with an alphabet of size a letters, where the usual choice is a 4; corresponding to the four bases of DNA. Each site on a genome mutates with rate m (per generation) to any of the a2 1 remaining letters with equal probability. DNA transfer events, in which ~~~
- The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit...errors. In addition, we removed sites with sequencing depth lower than 10 for all individuals or higher than 500 that likely belong to repetitive regions. The resulting dataset comprise 133,808 SNVs within the exome. This dataset was used solely for identifying absolute numbers of SNVs across a number ~~~
- Selection Limits to Adaptive Walks on Correlated Landscapes...in the weak-mutation regime and characterize the conditions that enable them to quickly reach the tness peak as a function of the number of sites under selection. We show that for additive landscapes there is a critical selection strength enabling populations to reach high-tness genotypes, regardless ~~~
- Inferring Ancestral Recombination Graphs from Bacterial Genomic Data...under a model of molecular evolution, which, in combination with a standard substitution model, includes effects similar to those resulting from gene conversion; instantaneous events that simultaneously produce character-state changes at multiple sites within a randomly positioned conversion tract ~~~
- Evolution of Resistance Against CRISPR/Cas9 Gene Drive...of homing endonuclease gene drives, rst proposed by Burt (2003), which consists of a genetic construct (driver allele) encoding an endonuclease that can cleave a genomic target site and Copyright 2017 by the Genetics Society of America doi: 10.1534/.116.197285 Manuscript received October 27, 2016 ~~~
- Statistical Methods for Identifying Sequence Motifs Affecting Point Mutations...:// bitbucket.org/pycogent3/mutationmotif. Materials and Methods Data sampling We infer mutation events in humans from published genetic variant records. Germline mutations were inferred from single nucleotide polymorphic (SNP) sites. Somatic mutations were inferred from genetic variants identied in cancers ~~~