242 Results
for term "sites"
- Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics...nucleotide site rather than per gene (Nei 1987). The proportion of polymorphic loci (P) was also introduced. This used the arbitrary criterion that a locus should show more than a single allele among the strains or individuals studied, and is little used today, although it is related to the estimator ~~~
- The Hiroshima/Nagasaki Survivor Studies: Discrepancies Between Results and General Perception...begetters of malformed offspring. While not reaching such extremes, the dominant present-day image of the aftermath of theHiroshima/ Nagasaki bombings, in line with the general perception of radiation risk (Ropeik 2013; Perko 2014), is that it left the sites heavily contaminated, that the survivors suffered ~~~
- Ellis Englesberg and the Discovery of Positive Control in Gene Regulation...and other cellular processes showing that gene induction involves new protein synthesis, in contrast, to previous theories where the inducer molecules mold the folding of enzyme active sites (Vogel 1957) Copyright 2014 by the Genetics Society of America doi: 10.1534/.114.167361 Manuscript received June ~~~
- Biochemical Genetics and Molecular Biology: The Contributions of George Beadle and Edward Tatum...can code multiple peptides as a result of multiple start sites and patterns of exon use and of the nature of protein structure make it clear that single peptides may participate in numerous reactions and that single proteins may participate in numerous developmental processes. In retrospect ~~~
- Ten Years of the Collaborative Cross...meeting. A committee from the CTC met the following year to debate the structure and specics of a breeding design that would mix and randomize multiple genomes into an experimental population where each recombination site was unique and whose size was sufciently powered to support QTL analysis at near ~~~
- Mutation and Human Exceptionalism: Our Future Genetic Load...is in the range of 1.11:73 1028 per nucleotide site per generation for base-substitution mutations alone (Lynch 2009; Campbell et al. 2012; Kong et al. 2012; ORoak et al. 2012; Sgurel et al. 2014; Besenbacher et al. 2015). The mutation rate to small insertion/deletions is 8% of the base-substitution rate (O ~~~
- The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics...ears. Although NCCs are not direct precursors of any part of the central nervous system (CNS) or of the adrenal cortex, they play important roles in the development of these tissues via postmigratory embryological interactions. In Figure 1, we indicate schematically the body sites affected in the DS ~~~
- The Evolving Definition of the Term “Gene”...that a single gene could produce more than one mRNA, and that one gene can be a part of several transcription units. This one-to-several relationship of genes to mRNAs occurs by means of complex promoters and/or alternative splicing of the primary transcript. Multiple transcription initiation sites, i ~~~
- Finding and Mapping New Genes Faster than Ever: Revisited.... An audience member at the conference asked: But Sydney, what about the regulatory regions? Brenner responded: We have to leave something for the next generation to work on. Second, Maynard Olsons idea of sequence-tagged sites (STSs) was broached. An STS is a pair of PCR primers that amplify a unique ~~~
- Medical Genetics and the First Studies of the Genetics of Populations in Mexico...S (HbS) was typical of the Northwest and central Africa, and was found at all sites where there had been immigration of black Africans. Hemoglobin C was typical of Western Africa, while hemoglobin E was almost exclusively from Southeast Asia. Correlating these data with those obtained for Mexican ~~~