44 Results
for term "sites"
- Chi...mutational step, Ken used size with recombination. The connection was made bya bio substitution that extended from att through gam the observations of Enquist and Skalka (1973), who(Figure 2), knocking out all the known site-specific and noted that recombination-deficient (red gam) phage generalized ~~~
- Speaking Out About the Social Implications of Science: The Uneven Legacy of H. J. Muller..., and his reputation. The shifting sites of Mullers workwhich ranged from Columbia University to Texas, from Berlin to Moscow and Leningrad, from Madrid to Edinburgh, and from Amherst to Indiana Universitymade his activism unusual. Muller paid a price for his activism, and his reputation today is still ~~~
- Thirty years ago in Genetics: prophage insertion into bacterial chromosomes....are integral parts of it. The two questions are closely intertwined. Had it transpired (as was frequently supposed prior to 1962, e.g., JACOB and WOLLMAN 1961) that a pro- phage could establish a permanent association with a chromosomal site by some means other than interca- lation, it would have been ~~~
- The Holliday junction on its thirtieth anniversary....of recombination had been hypothesized to account for heterozygous particles of phage T4 (- 1954). Then, enzymes analogous to enzymes proposed to repair UV damage could recognize violations of Watson-Crick pairing at the marked site and operate on the heteroduplex, removing a bit from one chain or the other ~~~
- Regulating tn10 and is10 transposition....may be either IHF or HU and which plays an accessory role in the reac- tion, probably by altering DNA structure. IHF is likely to be the most important host factor in vivo. TnIO and IS20 transpose by a nonreplicative mech- anism in which the element is excised from the donor site and inserted at a new ~~~
- The Hawthorne deletion twenty-five years later....know what HO does-it codes for a site-specific double-strand endo- nuclease that initiates mating type interconversion by cleaving the mating type locus (KOSTRIKEN et al. 1983; KOSTRIKEN and HEFFRON 1984). And we know the outlines of mating type interconversion-HO protein HMLa MATa HMRa - x ynz w HMLa ~~~
- The foundations of genetic fine structure: a retrospective from memory....and its functional allele asteroid (ast, then sr or Star reces- sive) occupied separate but contiguous chromosomal sites and therefore should be separable by crossing over. He set out to do this by looking for wild-type recombinants. The l z situation is a classical example of the BATESON ~~~
- Twenty-five years ago in genetics: the infinite allele model....of individual nucleotides. KIMURA ( 1 969) developed such a theory, sometimes called the infinite site model. This also appeared in an April issue of GENETICS, exactly 20 years ago. The number of nucleotide sites is, of course, enormous while the mutation rate per site is very small. The model as- sumes that ~~~
- Impact of the Douglas-Hawthorne model as a paradigm for elucidating cellular regulatory mechanisms in fungi....that regulates the expres- sion of GAL4 by interacting at a controlling site for GAL4 (the GAL81 site) in the absence of galactose. In the presence of galactose, the repressor is inactivated by its interaction with galactose and the GAL4 gene is expressed to produce a diffusible intermediary. This in turn exerts ~~~
- Remembering Rollin Hotchkiss (1911–2004)...of the marker region, indicative of multiple sites for breakage and exchange, can be recov-the part of some biochemists and geneticists who believed that miniscule amounts of protein could be re- ered in transformation (Fox and Hotchkiss 1957). In an analysis of the complex sulfonamide resistance locus ~~~