14 Results
for term "sites"
- The Hawthorne deletion twenty-five years later....know what HO does-it codes for a site-specific double-strand endo- nuclease that initiates mating type interconversion by cleaving the mating type locus (KOSTRIKEN et al. 1983; KOSTRIKEN and HEFFRON 1984). And we know the outlines of mating type interconversion-HO protein HMLa MATa HMRa - x ynz w HMLa ~~~
- The foundations of genetic fine structure: a retrospective from memory....and its functional allele asteroid (ast, then sr or Star reces- sive) occupied separate but contiguous chromosomal sites and therefore should be separable by crossing over. He set out to do this by looking for wild-type recombinants. The l z situation is a classical example of the BATESON ~~~
- Studies of yeast cytochrome c: how and why they started and why they continued....sequence of iso-1-cytochrome c was reported by NARITA et al. (1963), numerous cycl mutations were identified, their sites were determined by deletion mapping and, in collaboration with J. STEWART, their DNA se- quences were deduced from the amino acid alterations in revertant proteins (SHERMAN and STEWART ~~~
- Barbara McClintock (June 16, 1902-September 2, 1992)....between the instability of ring-shaped chromosomes and phenotypic variegation, the discov- ery that the centromere is divisible, and the identifi- cation of a chromosomal site essential for the forma- tion of the nucleolus. In the years following completion of her doctoral work, MCCLINTOCK continued her ~~~
- Intragenic recombination in Drosophila: the rosy locus....mutations representing a single com- plementation group. Utilizing a selective system to facilitate large-scale sampling, the resolving power of such recombination permitted the elaboration of a linear order of sites within a single gene, quite com- parable to that seen in prokaryotes and fungi. The second ~~~
- The evolution of somatic selection: the antibody tale....or another, the antigen or hapten served as a template for the folding of the antibodycombining site. An outstanding example was the proposal of PAULINC (1940). Within the 10-year period from 1959 to 1969, the whole picture changed. Immunology was thrust into prominence as a source of ideas [see EDELMAN ~~~
- Motoo Kimura (1924-1994)...., widely used in population , the infinite allele, the infinite site, and the lad- der models. I was associated with some of the work mentioned in these two paragraphs, a source of deep satisfaction to me, for I could never have done the mathematics alone. I shall not list KIMURAS papers ~~~
- The transformation of genetics by DNA: an anniversary celebration of Avery, MacLeod and McCarty (1944)....institutional arrangements today nurture such transdisciplinary and vertically integrated research, which is often the arena of the most revolutionary advances. Before the federalization of biomedical re- search financing since World War 11, The Rockefeller Institute was very nearly the only site where ~~~
- N. I. Vavilov, martyr to genetic truth....to be particularly rich in varieties, and he regarded these as the centers from which the crop plants were descended. These areas also were often the sites of origin of civilizations. In retrospect, the hypothesis has not stood up very well. Cultivated varieties have not regularly come from the areas of greatest ~~~
- Forty years ago in "Genetics": the unorthodox mating behavior of bacteria....chromosome at a specific site, losing the capacity to infect by cell-to-cell contact but acquiring the property of high-frequency recombina- tion. We communicated this finding to the Bellagio 1953 International Congress of Genetics together with the first information on recombination and fit- ness (CAVALLI ~~~