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  • The Spectrum of Acridine Resistant Mutants of Bacteriophage T4 Reveals Cryptic Effects of the tsL141 DNA Polymerase Allele on Spontaneous Mutagenesis
    Fei Jun Wang, Lynn S. Ripley
    Genetics April 1998 148: 1655-1665;
    ...a substantial alteration of delity by the mutant polymerase. The patterns of base substitution mutagenesis suggest that some site-specic mutation rate effects may reect hotspots for mutagenesis arising by different mechanisms. A new class of spontaneous duplication mutations, having sequences inconsistent ~~~
  • The lacI Gene as a Target for Mutation in Transgenic Rodents and Escherichia coli
    Johan G. de Boer, Barry W. Glickman
    Genetics April 1998 148: 1441-1451;
    ...mutations recovered from these animals increases, we are able to analyze the sites at which mutations have been recovered in great detail and to compare the recovered sites between bacteria and transgenic animals. The nucleotides that code for the DNA-binding domain are nearly saturated with base ~~~
  • The Chromosome Bias of Misincorporations During Double-Strand Break Repair Is Not Altered in Mismatch Repair–Defective Strains of Saccharomyces cerevisiae
    Carolyn B. McGill, Susan L. Holbeck, Jeffrey N. Strathern
    Genetics April 1998 148: 1525-1533;
    ...Biology Laboratory, National Cancer InstituteFrederick Cancer Research and Development Center, ABLBasic Research Program, Frederick, Maryland 21702-1201 ABSTRACT Recombinational repair of a site-specic, double-strand DNA break (DSB) results in increased reversion frequency for nearby mutations ~~~
  • Regulation of DNA Polymerase Exonucleolytic Proofreading Activity: Studies of Bacteriophage T4 “Antimutator” DNA Polymerases
    Linda J. Reha-Krantz
    Genetics April 1998 148: 1551-1557;
    ...and base analogue induced mutations. Other mutational pathways such as GCAT transitions, transversions, and frameshifts are not reduced at some sites by T4 antimutator DNA poly- Figure 1.Locations of mutations in the bacteriophage T4 merases, and may even be increased (Drake and Green- DNA polymerase ~~~
  • DNA Polymerase Fidelity: From Genetics Toward a Biochemical Understanding
    Myron F. Goodman, D. Kuchnir Fygenson
    Genetics April 1998 148: 1475-1482;
    ...of the base . . . [such that] the information antimutagenic T4 polymerase mutants (Drake and of the parental DNA strand is transmitted sequentially by the enzyme to an allosteric site where selection of theAllen 1968). Until then, mutations in the structural nucleotide . . . occurs. Such an enzymic mechanism ~~~
  • DNA Sequence Analysis of Spontaneous Mutagenesis in Saccharomyces cerevisiae
    Bernard A. Kunz, Karthikeyan Ramachandran, Edward J. Vonarx
    Genetics April 1998 148: 1491-1505;
    ...sequence may be indistinguishable phenotypically from locus reversion. Reversion systems will notbe considered furtherchanges that occur, the rates at which they arise, their site specicity, and how these parameters are inuenced in this review. Mutational spectra derived from different assay sys ~~~
  • A New Look at Old Mutants of T4 DNA Polymerase
    Nancy G. Nossal
    Genetics April 1998 148: 1535-1538;
    ...structure (reviewed in Joyce and and Ripley 1994; Reha-Krantz 1994; and Goodman Steitz 1994), RB69 polymerase is organized into anet al. 1993). exo domain with the active site for the proofreadingAmber mutants: My long and pleasant collaboration exonuclease, a ngers domain thought to be involved inwith Jan ~~~
  • Damage Control: The Pleiotropy of DNA Repair Genes in Drosophila melanogaster
    Jeff J. Sekelsky, Kenneth C. Burtis, R. Scott Hawley
    Genetics April 1998 148: 1587-1598;
    ...demonstrated that many of the mei or binds in a sequence-independent manner to DNA ends mus mutants also exhibited severe defects in mitotic chro- and in a sequence-dependent manner to internal sites mosome behavior (Baker et al. 1978; Gatti et al. 1980). (Knuth et al. 1990; Messier et al. 1993). In addition ~~~
  • Factors Affecting Inverted Repeat Stimulation of Recombination and Deletion in Saccharomyces cerevisiae
    Kirill S. Lobachev, Boris M. Shor, Hiep T. Tran, Wendy Taylor, J. Dianne Keen, Michael A. Resnick, Dmitry A. Gordenin
    Genetics April 1998 148: 1507-1524;
    ...) was gradually decreased. The URA3 fragment anked by inverted polylinkers from the 1.1 kb to 58 bp. The resulting quasipalindrome (named as InsQ) was recloned in centromere plasmid pFL39 (BonneaudpUC4K-IXX plasmid (Barany 1985) was cloned between either HpaI, EheI, XhoI, Eco47III, HindIII and BglII sites ~~~
  • Mutagenesis and More: umuDC and the Escherichia coli SOS Response
    Bradley T. Smith, Graham C. Walker
    Genetics April 1998 148: 1599-1610;
    ...by allowing it to process lesions that cannot be vitally important mechanisms, such as nucleotide exci- repaired in an error-free manner, e.g., an abasic site sion repair, to deal with DNA damage in an error-free opposite a break or a gap in the complementary DNA manner. When DNA damage cannot be repaired ~~~

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