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  • Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics December 2016 204: 1379-1390; https://doi.org/10.1534/genetics.116.189712
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 1
    Figure 1
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The results of different methods applied to a simulated data set. The x-axis shows SNP locations and the y-axis shows FormulaP-values of associations between each SNP and all the genes. Blue ↓ shows the location of the true trans-regulatory hotspots. (A) The result of the standard t-test. (B) The result of EMMA. For (A) and (B), we averaged the FormulaP-values over all of the genes for each SNP. (C) The result of MDMR. (D) The result of GAMMA.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 2
    Figure 2
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    An eQTL map of a real yeast data set. P-values are estimated from NICE (Joo et al. 2014). The x-axis corresponds to SNP locations and the y-axis corresponds to the gene locations. The intensity of each point on the map represents the significance of the association. The diagonal band represents the cis effects and the vertical bands represent trans-regulatory hotspots.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 3
    Figure 3
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The results of MDMR and GAMMA applied to a yeast data set. The x-axis corresponds to SNP locations and the y-axis corresponds to gene locations. The y-axis corresponds to −log10 of P-values. Blue * above each plot shows putative hotspots that were reported in a previous study (Joo et al. 2014) for the yeast data. (A) The result of MDMR. (B) The result of GAMMA.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 4
    Figure 4
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The results of the standard t-test and EMMA applied to a yeast data set. The x-axis corresponds to SNP locations and the y-axis corresponds to gene locations. The y-axis corresponds to sum of −log10 of P-value over the genes. Blue * above each plot shows putative hotspots that were reported in a previous study (Joo et al. 2014) in the yeast data. (A) The result of the standard t-test. (B) The result of EMMA.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 5
    Figure 5
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The result of GAMMA applied to a gut microbiome data set. The x-axis corresponds to SNP locations and the y-axis corresponds to gene locations. The y-axis corresponds to −log10 of P-value.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    View table
    Table 1
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The list of significant associations with a gut microbiome data set
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 6
    Figure 6
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The result of MDMR applied to chromosome 19 of a gut microbiome data set. The x-axis corresponds to SNP locations and the y-axis corresponds to gene locations. The y-axis corresponds to −log10 of P-value.
  • You have access
    Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure
    Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis, Eleazar Eskin
    Genetics Dec 2016, 204 (4) 1379-1390; DOI: 10.1534/genetics.116.189712
    Figure 7
    Figure 7
    By Jong Wha J. Joo, Eun Yong Kang, Elin Org, Nick Furlotte, Brian Parks, Farhad Hormozdiari, Aldons J. Lusis and Eleazar Eskin
    The results of the standard t-test and EMMA applied to a gut microbiome data set. The x-axis corresponds to SNP locations and the y-axis corresponds to gene locations. The y-axis corresponds to sum of −log10 of P-value over the genus. (A) The result of the standard t-test. (B) The result of EMMA.
  • Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data
    Eun Yong Kang, Lisa J. Martin, Serghei Mangul, Warin Isvilanonda, Jennifer Zou, Eyal Ben-David, Buhm Han, Aldons J. Lusis, Sagiv Shifman, Eleazar Eskin
    Genetics November 2016 204: 1057-1064; https://doi.org/10.1534/genetics.115.177246

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