Table 1 Functions of Pif1 family helicases
Pif1Rrm3Pfh1
Replication fork progression
 tDNAsB (1)Y (2)Y (3)
 G4 motifsY (4)B (5)Y (6)
 CentromeresB (7)Y (2)NT
 Telomeres(N)Y (8)Y (9)
 RFBN (10)Y (10)Y (3)
Support RFBY (10)N (10)N (3)
Separate converged forksY (11)Y (10, 12)Y (3, 13)
Maintain mtDNAY (14)NY (15)
Inhibit telomeraseY (16)N (8)N (9)
Promote BIRY (17)N (17)NT
Process Okazaki fragmentsY (18)Y (19)NT
  • References used: (1) Tran et al. 2017; Osmundsen et al. 2017; (2) Ivessa et al. 2003; (3) Sabouri et al. 2012; (4) Paeschke et al. 2011; Lopes et al. 2011; (5) Paeschke et al. 2013; (6) Sabouri et al. 2014; (7) This paper; (8) Ivessa et al. 2002; (9) McDonald et al. 2014; (10) Ivessa et al. 2000; (11) K. Labib, personal communication; (12) Fachinette et al. 2010; (13) Steinacher et al. 2012; (14) Foury and Kolodynski 1983; (15) Pinter et al. 2008; (16) Zhou et al. 2000; (17) Saini et al. 2003; Wilson et al. 2013; (18) Budd et al. 2006; and (19) Osmundsen et al. 2017. B, Backup role; Y, Yes; NT, not tested; (N), probably no; RFB, replication fork barrier; N, NO; BIR, break-induced replication.