Table 3 Linear models of transcriptional noise with genomic and epigenomic factors
OLSGLS
CoefficientSEP-valueCoefficientSEP-value
(Intercept)0.16120.07810.0392*0.16650.06630.0121*
PC10.03900.0065< 0.0001***0.03960.0065< 0.0001***
PC2−0.00480.00690.4854−0.00480.00690.4838
PC3−0.05260.0091< 0.0001***−0.05180.0092< 0.0001***
PC4−0.01020.00970.2905−0.01090.01000.2773
PC50.01170.01060.27130.01230.01060.2456
PC6−0.01520.01070.1536−0.01520.01090.1623
PC70.02100.01020.0384*0.02110.01100.0561.
PC80.01000.01130.37780.00730.01140.5250
TFPC10.00280.00410.49120.00250.00340.4658
TFPC20.00250.00270.36640.00240.00260.3585
TFPC30.00320.00420.45130.00320.00370.3825
HistPC1−0.00310.0010.0015**−0.00330.00100.0007***
HistPC2−0.00270.00160.0846.−0.00290.00150.0566.
  • All correlations are computed using Kendall’s rank correlation test, with P-value codes defined as *** < 0.001 < ** < 0.01 < * < 0.05 < . < 0.1. OLS, Ordinary Least Squares; GLS, Generalized Least Squares; Pathway PC1–8, principal components on centrality measures, protein conservation, and gene age; TFPC1–3, principal components of the logistic PCA on transcription factor binding evidence; HistPC1 and 2, principal components of the logistic PCA on histone modification marks.