Table 2 Correlation of transcriptional noise with gene centrality measures and pleiotropy, as estimated from pathway annotations and PPI networks
DataMeasureCorrelation with F*P-value
PathwaysDegree−0.07451.14 × 10−13***
Hub score−0.08086.61 × 10−16***
Authority score−0.06662.72 × 10−11***
Clustering coefficient−0.07944.55 × 10−15***
Closeness−0.02541.09 × 10−02*
Betweenness−0.01758.65 × 10−02.
Pleiotropy−0.05148.31 × 10−07***
Size−0.05143.91 × 10−03***
Diameter0.00617.55 × 10−01 (NS)
Global transitivity−0.15323.06 × 10−17***
PPIDegree−0.02498.20 × 10−03**
Hub score−0.0942< 2.2 × 10−16***
Transitivity−0.03386.24 × 10−04***
Betweenness−0.01401.31 × 10−01 (NS)
  • All correlations are computed using Kendall’s rank correlation test, with P-value codes defined as *** < 0.001 < ** < 0.01 < * < 0.05 < . < 0.1. NS, nonsignificant; PPI, protein–protein interaction.