Meiotic pathway | Mitotic pathway | Observed per 1000 | Meiotic pathway | Mitotic pathway | Calculated total | |
---|---|---|---|---|---|---|

6:2 | B[gD + (1 − g)D/2] | BP[g + (1 − g)um] | 55.5 | 15.8 | 39.6 | 55.5 |

2:6 | (1 − B)[gD + (1 − g)D/2] | (1 − B)P[g + (1 − g)un] | 64.1 | 27.4 | 36.7 | 64.1 |

5:3 | 0 | BP(1 − g)(1 − u) | 8.1 | 0 | 6.1 | 6.1 |

3:5 | 0 | (1 − B)P(1 − g)(1 − u)) | 8.7 | 0 | 10.6 | 10.6 |

Since HC ratios are unperturbed by MMR disparity (Detloff

*et al.*1991), the ratio 5:3/3:5 is*B*/(1 −*B*), giving the expectations 5:3 = 6.1 and 3:5 = 10.6. The numbers of 6:2 and 2:6 tetrads contributed by the meiotic pathway were calculated using*B*= 0.365 and*g*= 0.08.*P*= 216,*D*= 80 from Table A4. These were subtracted from the total observed values to get the mitotic pathway values. From the ratio of mitotic pathway FC numbers, the ratio*m/n*= 2.2 can be obtained, independently of*u*, and, thus, independently of any assumption about whether all acts of unwinding render a mismatch eligible for repair. Evaluating*u*from the sum 5:3 + 3:5 gives*u*= 0.915.