Table A1 Parameters needed to specify the 12 tetrad classes in Table 5
ParameterDescription
BFraction of DSBs at the His4 hotspot that occur on the his4-ATC chromosome (breakage index); applicable to both DSB-repair pathways (Figure 1B).
DNumber of meiotic pathway events that involve the his4-ATC site in a mismatch.
PNumber of mitotic pathway events that involve the his4-ATC site in a mismatch.
gProbability of FC by double-strand gapping; assumed applicable to both DSB-repair pathways (Figure 1B).
vProbability, in mitotic pathway only, of unwinding a mismatch in the MMR-deficient crosses in a manner that restores 4:4 segregation (e.g., Figure 1E).
uProbability, in mitotic pathway only, of unwinding a mismatch in the MMR-proficient cross; results in either an FC or a restoration, depending on the reparability of the mismatch (e.g., Figure 1E).
mProbability of MMR of G/G, giving a 6:2 tetrad; contingent on DNA unwinding in the mitotic pathway.
nProbability of MMR of C/C, giving a 2:6 tetrad; contingent on DNA unwinding in the mitotic pathway.